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Encyclopedia > Ceruloplasmin
Ceruloplasmin
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Ceruloplasmin

Ceruloplasmin (or caeruloplasmin), officially known as ferroxidase or iron(II):oxygen oxidoreductase, is a copper transport protein found in the blood. It is an enzyme (EC 1.16.3.1). Image File history File links Gen w/ Deepview from PDB:1KCW File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ... Image File history File links Gen w/ Deepview from PDB:1KCW File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Ribbon diagram of the catalytically perfect enzyme TIM. An enzyme is a protein that catalyzes, or speeds up, a chemical reaction. ... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ...

Contents


Interpretation

Decreased levels

Lower than normal ceruloplasmin levels may indicate:

Menkes disease, also called the kinky hair disease or Menkes kinky hair syndrome, is a disease of abnormal copper metabolism. ... Wilsons disease or lentigohepatic degeneration is an autosomal recessive hereditary disease, with an incidence of about 1 in 30,000. ...

Elevated levels

Greater than normal ceruloplasmin levels may indicate:

A pregnant woman It is the carrying of one or more embryos or foeti by female mammals, including humans, inside their bodies. ... Lymphoma is a general term for malignancies of lymphocytes or, more rarely, of histiocytes. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... Acute phase proteins are a class of proteins that are synthetized in the liver in response to inflammation. ... Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ...

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  Results from FactBites:
 
Tissue-specific ceruloplasmin gene expression in the mammary gland. (275 words)
Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals.
Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus.
Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma.
INABIS '98 - Aceruloplasminemia (1575 words)
Ceruloplasmin is a member of the highly conserved family of blue multicopper oxidases and is encoded in a 19 exon, single copy, 40 kB gene in the haploid human genome (1).
Ceruloplasmin is thus responsible for moving iron out of the storage compartment of the reticuloendothelial system to the functional compartment of the bone marrow following recycling of senescent red blood cell iron mass.
A defect in ceruloplasmin synthesis that results in aceruloplasminemia causes cellular damage due to (1) storage damage from excessive iron deposition, (2) oxyradical damage secondary to the presence of a free transition metal and H2O2 within the cell or (3) a lack of substrate and a failure of the functional compartment.
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