In the Star Trek fictional universe, the Challenger class is a variety of starship used by Starfleet.

Challenger class starships:

• U.S.S. Armstrong - Registry number NCC-57537
  • The Armstrong was ambushed by a Klingon battle group in 2373 and took heavy casualties. After the battle, the Armstrong docked at Deep Space 9 to receive medical aid. Named for Apollo 11 astronaut Neil Armstrong, the first human to set foot on Earth's moon.

• U.S.S. Buran - Registry number NCC-57580
  • The Buran was one of the 39 starships destroyed by the Borg in the battle of Wolf 359. The Buran was a "kit bashed" study model barely glimpsed among the wreckage of the "graveyard". The ship was named for the Russian space shuttle, which was in turn named for the Russian word for "snowstorm".

• U.S.S. Kearsage - Registry number NCC-57566
  • A scheduled rendezvous of the Kearsage with the Enterprise-D in 2370 was postponed for four days, allowing Worf and his son Alexander to attend the Kot'baval Festival. Named for the American aircraft carrier that served as the recovery vessel for Alan Shepard's Freedom Seven Mercury spacecraft.