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Encyclopedia > Chemokine receptor
Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic "DRY" motif in the second intracellular domain. Chemokine receptors are usually linked to a G-protein through which they signal.
Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic "DRY" motif in the second intracellular domain. Chemokine receptors are usually linked to a G-protein through which they signal.

Chemokine receptors are G-protein-linked 7-transmembrane receptors expressed on the surfaces of certain cells. G-proteins, short for guanine nucleotide binding proteins, are a family of proteins involved in second messenger cascades. ... G-proteins, short for guanine nucleotide binding proteins, are a family of proteins involved in second messenger cascades. ...


They interact with small extracellular protein ligands known as chemokines. Following interaction with their specific ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling), which generates a chemotactic response of that cell, thus trafficking the cell to a desired location within the organism. These chemokine receptors are divided into different families according to which family of chemokines they bind (CC, CXC, C, or CX3C). In chemistry, a ligand is an atom, ion or functional group that is bonded to one or more central atoms or ions, usually metals generally through co-ordinate covalent bond. ... Chemokines are a class of chemotactic cytokines, or small secreted protein signals. ... In cell biology, molecular biology and related fields, the word intracellular means inside the cell. It is used in contrast to extracellular (outside the cell). ... Calcium ions act as second messengers in signal transduction. ...


Families

  • C chemokine receptors (one member, XCR1)
  • CX3C chemokine receptors (one member, CX3CR1)

Further reading

  • Murphy, International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature, Pharmacological Reviews, 2002, 54:227-229.
  • Murphy et al., International union of pharmacology. XXII. Nomenclature for chemokine receptors, Pharmacological Reviews, 2002, 52:145-76.
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Image File history File links Commons-logo. ... Wikimedia Commons logo by Reid Beels The Wikimedia Commons (also called Commons or Wikicommons) is a repository of free content images, sound and other multimedia files. ... Image File history File links Commons-logo. ... Wikimedia Commons logo by Reid Beels The Wikimedia Commons (also called Commons or Wikicommons) is a repository of free content images, sound and other multimedia files. ...

External links

  • IUPHAR RECEPTOR DATABASE
  • The Cytokine Receptor Database


 

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