The Chenango River is a tributary of the Susquehanna River, approximately 90 mi (145 km) long, in central New York in the United States. It drains a dissected plateau area in upstate New York at the northern end of the Susquehanna watershed.

It rises in Madison, approximately 20 mi (32 km) southwest of Utica. It flows generally past Sherburne to Norwich, where it turns southwest, flowing past Greene, and Chenango Forks, where it receives the Tioughnioga River. It join the Susquehanna from the north in downtown Binghamton.

In the 19th century the river furnished a critical link the canal system of the northeastern United States. The Chenango Canal, built from 1836-1837 between Utica and Binghamton, connected the Erie Canal in the north to the Susquehanna River. The canal was rendered obsolete by railroads and was abandoned in 1878.

See also

• List of New York rivers