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Chimera (virus) defined

The term chimera was originally defined as an individual organism whose body contained cell populations from different zygotes or an organism that developed from portions of different embryos. The USDA Center for Veterinary Biologics refined this definition as it refers to vaccines, stating that the term chimera is to be used for a, “new hybrid microorganism created by joining nucleic acid fragments from two or more different microorganisms in which each of at least two of the fragments contain essential genes necessary for replication.”