In 1796, Chief Seckas of the Thames River brought 170 warriors to the seige of Detroit during Pontiac's uprising. The reserve was established in 1819, as part of a treaty by which the Chippewa of the Thames sold 552,000 acres (2,234 kmē) of land to the British for an annuity of Ģ600 and the establishment of two reserves, of which reserve no. 42 is the larger. In 1840 the Chippewa reached an agreement with the Munsee-Delaware Nation to share the reserve. The Munsee portion of the reserve became part of the new Munsee_Delaware Nation No. 1 reserve in 1967.
The Thames River watershed hosts 15% of the species at risk in Canada and is particularly noted for its aquatic species (fish spp., mussel spp., and Spiny Softshell turtle).
The Thames River drains an area of 5825 sq km in southwestern Ontario that lies within the counties of Perth, Middlesex, Oxford, Elgin, Chatham-Kent and Essex.
To stabilize and enhance species at risk populations within the Thames River ecosystem, and to reduce or eliminate the threats to these species and their associated habitats, so that their long-term survival in the natural environment is ensured, using an ecosystem management-based approach.