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Encyclopedia > Chlorphenamine


Chlorphenamine

(3RS)-3-(4-chlorophenyl)-N,N-dimethyl-
3-(pyridin-2-yl)propan-1-amine
CAS number
132-22-9
ATC code
 ?
Chemical formula C16H19ClN2
Molecular weight 274.8
Bioavailability 25-50%
Metabolism hepatic
Elimination half-life 6.3-23.1 hours
Excretion renal
Australia)
Legal status Schedule 3 (Australia)
Routes of administration oral


Chlorphenamine (INN) or chlorpheniramine (USAN, former BAN), commonly marketed as its salt chlorphenamine maleate (CPM), is first-generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria.


CPM is one of the main ingredients in many OTC allergy medications, such as Coricidin Cough & Cold (or CCC). Many people use Coricidin recreationally for the dextromethorphan content; however, this is strongly recommended against. In high doses, chlorpheniramine maleate can cause severe allergic reactions and has been linked to at least twelve deaths in the United States.


External links

  • The Coricidin Harm Reduction Project (http://www.coricidin.org)

  Results from FactBites:
 
Chlorphenamine injection , SPC from the eMC (1079 words)
Chlorphenamine injection is indicated for acute urticaria, control of allergic reactions to insect bites and stings, angioneurotic oedema, drug and serum reactions, desensitisation reactions, hayfever, vasomotor rhinitis, severe pruritus of non-specific origin.
Chlorphenamine injection may be helpful in the prevention of delayed reactions to penicillin and other drugs when given separately by intramuscular injection immediately prior to administration of the other drug.
Chlorphenamine, in common with other drugs having anticholinergic effects, should be used with caution in epilepsy; raised intra-ocular pressure including glaucoma; prostatic hypertrophy; severe hypertension or cardiovascular disease; bronchitis; bronchiectasis and asthma; hepatic disease and thyrotoxicosis.
Calimal Antihistamine Tablets (797 words)
Chlorphenamine acts by blocking the binding of histamine to receptors in the body and so preventiing or relieving the typical symptoms of an allergic reaction.
Chlorphenamine tablets or syrup are useful for both the prevention or relief of localised or less serious allergies such as hay fever or itchy rash and some more serious allergic reactions such as angioneurotic oedema.
Chlorphenamine is called a sedating antihistamine as it enters the brain in significant quantities and is therefore more likely to cause drowsiness than the newer group of non-sedating antihistamines.
  More results at FactBites »


 
 

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