FACTOID # 60: Japan's water has a very high dissolved oxygen concentration - but not enough to prevent drowning in the bath.
 
 Home   Encyclopedia   Statistics   Countries A-Z   Flags   Maps   Education   Forum   FAQ   About 
 
 
 
WHAT'S NEW
RECENT ARTICLES
More Recent Articles »
 

SEARCH ALL

FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:

 

 

(* = Graphable)

 

 


Encyclopedia > Chlorpheniramine maleate


Chlorphenamine

(3RS)-3-(4-chlorophenyl)-N,N-dimethyl-
3-(pyridin-2-yl)propan-1-amine
CAS number
132-22-9
ATC code
 ?
Chemical formula C16H19ClN2
Molecular weight 274.8
Bioavailability 25-50%
Metabolism hepatic
Elimination half-life 6.3-23.1 hours
Excretion renal
Australia)
Legal status Schedule 3 (Australia)
Routes of administration oral


Chlorphenamine (INN) or chlorpheniramine (USAN, former BAN), commonly marketed as its salt chlorphenamine maleate (CPM), is first-generation antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria.


CPM is one of the main ingredients in many OTC allergy medications, such as Coricidin Cough & Cold (or CCC). Many people use Coricidin recreationally for the dextromethorphan content; however, this is strongly recommended against. In high doses, chlorpheniramine maleate can cause severe allergic reactions and has been linked to at least twelve deaths in the United States.


External links

  • The Coricidin Harm Reduction Project (http://www.coricidin.org)

  Results from FactBites:
 
Procedure for encapsulating chlorpheniramine - Patent 5622723 (1792 words)
An improvement in the process of coacervation of chlorpheniramine maleate is provided whereby a predetermined amount of chlorpheniramine maleate charged to the process is maintained in the microcapsules by pre-saturating the coacervation medium with chlorpheniramine maleate.
The chlorpheniramine maleate to be encapsulated can be added to the pretreated cyclohexane alone or in conjunction with another pharmaceutical material, such as pseudoephedrine hydrochloride, with which it is commonly administered in a combined dosage form.
Chlorpheniramine maleate should be heated with the cyclohexane as a first step to saturate the cyclohexane and the other ingredients can be added following standard microencapsulating procedure at a temperature sufficiently high to dissolve the ethylcellulose and the polyethylene.
NTP: Abstract for TR-317 - Chlorpheniramine Maleate (898 words)
Doses originally selected for male mice in the 2-year study were 0, 100, or 200 mg/kg; however, because of poor survival, that study was stopped and a new study was started at doses of 0, 25, or 50 mg/kg.
Chlorpheniramine maleate was not mutagenic to Salmonella strains TA98, TA100, TA1535, or T1537 in the presence or absence of S9 metabolic activation systems prepared from the liver of Aroclor 1254-treated male Sprague-Dawley rats or male Syrian hamsters.
Chlorpheniramine maleate had a proliferative effect in the thyroid gland of female mice, as shown by the increased incidences of follicular cell cysts and hyperplasia in both low dose and high dose groups.
  More results at FactBites »


 
 

COMMENTARY     


Share your thoughts, questions and commentary here
Your name
Your comments

Want to know more?
Search encyclopedia, statistics and forums:

 


Lesson Plans | Student Area | Student FAQ | Reviews | Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms, 1022, m