Chlorpropamide is a sulphonylurea drug used to treat type 2 diabetes mellitus. Its renal clearance and long half-life cause hypoglycemia as a side-effect more frequently than newer sulphonylureas. Diabetes mellitus is a medical disorder characterized by varying or persistent hyperglycemia (elevated blood sugar levels), especially after eating. ... Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ... Hypoglycemia is a medical term referring to a pathologic state produced by a lower than normal amount of sugar (glucose) in the blood. ... A side-effect is any effect other than an intended primary effect. ...
Chlorpropamide may interact with other drugs, enhancing its effects, leading to low blood sugar; and some drugs may increase blood sugar levels, leading to loss of control by Chlorpropamide.
Chlorpropamide is not usually prescribed for pregnant women as it may decrease blood glucose in the fetus and cause birth defects.
Chlorpropamide passes into breast milk, and it is not recommended that a woman breast feed while taking the drug, as it may cause low blood sugar in the baby.
The inability to control blood glucose in type II diabetes is caused by reduced insulin release by the pancreas as well as decreased removal of glucose from the blood by the body's cells.
Alcohol may interact with the first generation sulfonylureas, especially chlorpropamide, to cause moderate to severe facial flushing (increased flow of blood to the face) and an increase in facial temperature.
Blood levels of digoxin (Lanoxin) may be increased by sulfonylureas, and, therefore, digoxin should be used cautiously with chlorpropamide and other first generation sulfonylureas.
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