Cholecystokinin receptors or CCK receptors are a group of G_protein coupled receptors. There are two different subtypes CCK1 and CCK2. They are ~50% homologous. The CCK1 receptor binds mostly to CCK while CCK2 also binds to gastrin. They are mostly involved in various digestive functions like gastrin-stimulated gastric acid secretion, gastric emptying and gut motility. In the brain, CCK functions as a neuropeptide and CCK receptors are involved in nociception, anxiety, memory and hunger.
The gut hormone cholecystokinin (CCK) is synthesised in endocrine I cells in the mucosa of the upper small intestine [1] and is released into the blood after ingestion of fatty and protein-rich meals [2].
CCK acts on receptors on afferent vagal nerves to stimulate the oxytocin release from the pituarity [12], and these receptors are present throughout the GI tract [3-5].
Receptors for PYY have been found in the kidney and on hepatocytes, and PYY influences the renal and hepatocyte metabolism [32-34].
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