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Encyclopedia > Chromium deficiency
Chromium deficiency
Classification & external resources
Chromium
ICD-10 E61.4
DiseasesDB 2625

Chromium deficiency is a disorder that results from an insufficient dietary intake of chromium. It occurs rarely in developed nations. Chromium table image created for Wikipedia by Schnee on June 25, 2003, 10:50 UTC. File links The following pages link to this file: Chromium User:Femto/elements e4 Categories: GFDL images ... General Name, Symbol, Number chromium, Cr, 24 Chemical series transition metals Group, Period, Block 6, 4, d Appearance silvery metallic Atomic mass 51. ... The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ... // E00-E35 - Endocrine diseases (E00-E07) Disorders of thyroid gland (E00) Congenital iodine-deficiency syndrome (E01) Iodine-deficiency-related thyroid disorders and allied conditions (E02) Subclinical iodine-deficiency hypothyroidism (E03) Other hypothyroidism (E030) Congenital hypothyroidism with diffuse goitre (E031) Congenital hypothyroidism without goitre (E032) Hypothyroidism due to medicaments and other... The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... General Name, Symbol, Number chromium, Cr, 24 Chemical series transition metals Group, Period, Block 6, 4, d Appearance silvery metallic Atomic mass 51. ... A developed country is a country that has achieved (currently or historically) a high degree of industrialization, and which enjoys the higher standards of living which wealth and technology make possible. ...

Contents

Use of chromium in the body

Trivalent chromium is an essential trace metal and is required for the proper metabolism of sugar in humans. Trivalent chromium has been found to be the key constituent in Glucose Tolerance Factor. Glucose tolerance factor (GTF)is a metal-protein complex that is formed when the oligopeptide chromodulin, which consists of the four amino acid residues aspartate, cysteine, glutamate, and glycine, is bonded with four chromic trivalent (Cr3+) ions in a tetranuclear orientation. Recent studies have suggested that this metal-protein complex plays an important role in insulin receptor activityby enhancing the efficiency of insulin. In contrast, hexavalent chromium is very toxic and mutagenic. In chemistry, valency is the power of an atom of an element to combine with other atoms measured by the number of electrons which an atom will give, take, or share to form a chemical compound. ... Trace metals are metals in extremely small quantities, almost at the molecular level, that reside in or are present in animal and plant cells and tissue. ... Magnification of typical sugar showing monoclinic hemihedral crystalline structure. ... Trinomial name Homo sapiens sapiens Linnaeus, 1758 Humans, or human beings, are bipedal primates belonging to the mammalian species Homo sapiens (Latin: wise man or knowing man) under the family Hominidae (the great apes). ... Chromium hexavalent Cr(VI) compounds, often called hexavalent chromium, exist in several forms. ... In biology, a mutagen (Latin, literally origin of change) is an agent that changes the genetic information (usually DNA) of an organism and thus increases the number of mutations above the natural background level. ...


Recently it was shown that the popular dietary supplement chromium picolinate generates chromosome damage in hamster cells. In the United States, the dietary guidelines for daily chromium uptake were lowered from 50-200 µg for an adult to 35 µg (adult male) and to 25 µg (adult female).[1] Chromium picolinate is a bright red solid that is the chromium (III) salt of picolinic acid. ... Genera Mesocricetus Phodopus Cricetus Cricetulus Allocricetulus Cansumys Tscherskia A hamster is a rodent belonging to the subfamily Cricetinae. ...


Treatment

Chromium picolinate is the most commonly used synthetic supplement to correct imbalances in glucose metabolism due to chromium deficency. This complex enters the cells in the body through a different mechanism compared to how trivalent chromium found naturally in food does and for this reason the safety or this supplement is debatable. For chromium to be used in the cells it must be released from chromium picolinate, in a process in which there is a reduction in the chromic center. This process can possibly lead to the formation unsafe hydroxyl radicals. Although it has been debated whether or not supplementation should be given regularly, studies have shown that chromium picolinate may be effective when given to patients receiving total parenteral nutrition (TPN), and as a result it is added regularly to TPN solutions. Image File history File links Chromium_picolinate. ... Image File history File links Chromium_picolinate. ... Chromium picolinate is a bright red solid that is the chromium (III) salt of picolinic acid. ... It has been suggested that this article or section be merged with carbohydrate catabolism. ... Total parenteral nutrition (TPN), is the practice of feeding a person without using the gut, i. ...


Trivalent chromium is found in a wide range of foods including: egg yolks, whole-grain products, high-bran breakfast cereals, coffee, nuts, green beans, broccoli, meat, brewer’s yeast, and some brands of wine and beer.


References

  1. ^ John B. Vincent (2004). Recent advances in the nutritional biochemistry of trivalent chromium. Proceedings of the Nutrition Society, 63, 41 - 47.

John B. Vincent. (2000). The Biochemistry of Chromium. The Journal of Nutrition,130: 715- 718.


William T. Cefalu and Frank B. Hu. (2004). Role of Chromium in Human Health and in Diabetes. Diabetes Care,27:2741-2751.


External links


  Results from FactBites:
 
Chromium (701 words)
Chromium is essential to proper insulin action and increases the body’s sensitivity to insulin.
Chromium is a key component of glucose tolerance factor (GTF), a substance that works with insulin to facilitate the uptake of glucose (blood sugar) into the cells.
Chromium deficiency is common in these patients and may contribute to both insulin resistance and elevations in cholesterol and triglyceride levels.
Chromium - Supplements (1174 words)
Chromium forms part of a compound in the body known as glucose tolerance factor (GTF), which is involved in regulating the actions of insulin in maintaining blood sugar levels and, possibly, in helping to control appetite.
Chromium is notorious for its poor absorption by the body, so many supplements are typically combined with another, more efficiently absorbed compound such as a vitamin (like niacin in polynicotinate versions) or an amino acid derivative (like picolinic acid, a derivative of tryptophan, in picolinate versions).
Chromium deficiency is not unknown in the United States and is thought to contribute to insulin resistance in many people.
  More results at FactBites »


 

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