Chromosome 15q partial deletion is an extremely rare genetic disorder, caused by a chromosomal aberration in which one of the long ("q") arms of humanchromosome 15 is deleted.
If the mother's copy of the chromosomal arm is deleted, Angelman syndrome results. If the father's copy of the chromosomal arm is deleted, Prader_Willi syndrome results.
A partial charge is a charge with an absolute value of less than one elementary charge unit (that is, smaller than the charge of the electron).
Partial atomic charges are used in molecular dynamics force fields to compute the electrostatic interaction energy using Coulomb's law.
Despite its usefulness, the concept of a partial atomic charge is somewhat arbitrary, because it depends on the method used to delimit between one atom and the next (in reality, atoms have no clear boundaries).
Maternal uniparental disomy for chromosome 15 leads to PWS because the genes on the chromosome 15 that should have been inherited from the father are missing.
PWS is caused by absence of the paternally derived PWS/AS region of chromosome 15 (15q11-13) by one of several genetic mechanisms, including uniparental disomy, imprinting mutations, chromosome translocations, and gene deletions.
(Interestingly, a deletion on the maternal chromosome causes Angelman syndrome.) This is the first known instance of imprinting in humans, and is a fascinating model of this genetic phenomena.
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