Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 155 million base pairs (the building material of DNA) and represents between 4.5 and 5 % of the total DNA in cells. Image File history File links No higher resolution available. ... Figure 1: A representation of a condensed eukaryotic chromosome, as seen during cell division. ... Trinomial name Homo sapiens sapiens Linnaeus, 1758 Humans, or human beings, are bipedal primates belonging to the mammalian species Homo sapiens (Latin: wise man or knowing man) in the family Hominidae (the great apes). ... Base pairs, of a DNA molecule. ... The structure of part of a DNA double helix Deoxyribonucleic acid, or DNA, is a nucleic acid molecule that contains the genetic instructions used in the development and functioning of all known living organisms. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hooke from Micrographia which is the origin of the word cell. Cells in culture, stained for keratin (red) and DNA (green). ...

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 8 likely contains between 700 and 1,000 genes. For a non-technical introduction to the topic, see Introduction to Genetics. ...

Genes

The following are some of the genes located on chromosome 8:

• FGFR1: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
• GDAP1: ganglioside-induced differentiation-associated protein 1
• LPL: lipoprotein lipase
• MCPH1: microcephaly, primary autosomal recessive 1
• NDRG1: N-myc downstream regulated gene 1
• NEF3: neurofilament 3 (150kDa medium)
• NEFL: neurofilament, light polypeptide 68kDa
• SNAI2: snail homolog 2 (Drosophila)
• TG: thyroglobulin
• TPA: tissue plasminogen activator
• WRN: Werner Syndrome

Fibroblast growth factor receptor 1 is a fibroblast growth factor receptor associated with Pfeiffer syndrome. ... Fibroblast growth factor, or FGF, is a family growth factors involved in wound healing. ... Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain bones of the skull (craniosynostosis), which prevents further growth of the skull and affects the shape of the head and face. ... Lipoprotein lipase (EC 3. ... Lipoprotein lipase (EC 3. ... Microcephalin is a gene determining human brain size in molecular evolution. ... Thyroglobulin is a protein secreted by the thyroid gland. ... Thyroglobulin is a protein secreted by the thyroid gland. ... In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... WRN (Werner syndrome) is a human gene that provides instructions for producing Werner protein, which is a type of enzyme called a helicase. ...

Diseases & disorders

The following diseases are some of those related to genes on chromosome 8:

• Charcot-Marie-Tooth disease
• Charcot-Marie-Tooth disease, type 2
• Charcot-Marie-Tooth disease, type 4
• congenital hypothyroidism
• familial lipoprotein lipase deficiency
• Primary microcephaly
• Hereditary Multiple Exostoses
• Pfeiffer syndrome
• Rothmund-Thomson syndrome, or poikiloderma congenitale
• Waardenburg syndrome
• Werner syndrome

Charcot-Marie-Tooth disease (CMT), known also as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is a heterogeneous inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms... To meet Wikipedias quality standards, this article may require cleanup. ... Charcot-Marie-Tooth disease, known also as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is a heterogeneous inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in... Congenital hypothyroidism (CHT) is a condition of thyroid hormone deficiency present at birth. ... Hereditary Multiple Exostoses (HME) is a medical condition whereby multiple exostoses (bony spurs or lumps, also known as osteochondromas) develop on the bones of a child. ... Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain bones of the skull (craniosynostosis), which prevents further growth of the skull and affects the shape of the head and face. ... Waardenburg syndrome is a rare genetic disorder most often characterized by varying degrees of deafness, minor defects in structures arising from the neural crest, and pigmentation anomalies. ... Werner syndrome is a very rare, autosomal recessive disorder; its most recognizable characteristic is premature aging. ...

References

• Gilbert F (2001). "Chromosome 8". Genet Test 5 (4): 345-54. PMID 11960583. 
• Nusbaum C et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature 439 (7074): 331-5. PMID 16421571.