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Methoxyflurane Anesthesia Augments The Chronotropic And Dromotropic Effects of Verapamil (0 words) |
 | The purpose of this study was to assess the effects of anesthesia with methoxyflurane (MF) on the dromotropic and chronotropic effects of verapamil (VER) in the rat. |
| The R-wave is produced during contraction of the ventricles and the entire QRS complex reflects ventricular depolarization and the T-wave, ventricular repolarization (20). |
| VER is a potent negative chronotrope (12), and the small dose used in this study did result in a 6% prolongation in RR-interval. |
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| Chronotropic incompetence was assessed if individuals failed to reach at least 85% of their age-predicted maximal heart rate or had a chronotropic index less than 0.8. |
| Chronotropic incompetence was more common at older ages, in smokers, and in those with a history of DM, HTN, COPD, known CAD, and with use of calcium channel blockers, digoxin or nitrates. |
| Chronotropic incompetence alone carried approximately the same mortality risk as thallium perfusion defects alone and the presence of both was associated with a substantially higher risk of death. |
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