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Encyclopedia > Ciclopirox
Ciclopirox
Systematic (IUPAC) name
6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one
Identifiers
CAS number 29342-05-0
ATC code D01AE14 G01AX12
PubChem 2749
DrugBank APRD00871
Chemical data
Formula C12H17NO2 
Mol. mass 207.269 g/mol
Pharmacokinetic data
Bioavailability <5% with prolonged use
Protein binding 94 to 97%
Metabolism  ?
Half life 1.7 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links This is a lossless scalable vector image. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... A drugs efficacy may be affected by the degree to which it binds to the proteins within blood plasma. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status

℞-only(US) OTC(CA) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained. ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from... Motto (Latin for From Sea to Sea) Anthem O Canada Royal anthem: God Save the Queen Capital Ottawa Largest city Toronto Official languages English, French Government Parliamentary democracy and federal constitutional monarchy  -  Monarch Queen Elizabeth II  -  Governor General Michaëlle Jean  -  Prime Minister Stephen Harper Establishment  -  Act of Union February...

Routes Topical (applied as a nail lacquer)

Ciclopirox olamine (also called Loprox®, Penlac® and Stieprox®) is a synthetic antifungal agent for topical dermatologic use. It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase (Niewerth et al., 2003). In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Something antifungal kills or inhibits the growth of fungus. ... Dermatology (from Greek derma, skin) is a branch of medicine dealing with the skin and its appendages (hair, nails, sweat glands etc). ...

v • d • e
Antifungals (D01 and J02)
Antibiotics Griseofulvin • Hitachimycin • Natamycin • Nystatin
Topical Azoles Clotrimazole • Econazole • Fluconazole • Ketoconazole • Miconazole • Oxiconazole • Sertaconazole • Sulconazole • Tioconazole
Other topicals Ciclopirox • Ethylparaben • Flucytosine, Salicylic acid • Selenium sulfide • Terbinafine • Tolnaftate • Undecylenic acid
For systemic use Amphotericin B • Anidulafungin • Caspofungin • Griseofulvin • Itraconazole • Posaconazole • Terbinafine • Voriconazole
Other Thiabendazole • Tea tree oil

  Results from FactBites:
 
Ciclopirox topical Information on Healthline (1207 words)
Ciclopirox topical cream and lotion formulations are used to treat skin infections such as athlete's foot, jock itch, ringworm, and yeast infections.
Ciclopirox shampoo is used to treat seborrheic dermatitis (inflammatory skin condition) of the scalp.
Ciclopirox topical nail lacquer is used to treat fungal infections of the toenails and fingernails.
Infectious Disease News: Ciclopirox treats onychomycosis (1246 words)
Ciclopirox has also been shown to affect the degradation of toxic peroxides in the fungal cell, decrease uptake of nutrients into the cell and disrupt the fungal cell membrane.
Complete cure (defined as clear nail and negative mycology) was achieved by six of 110 (5.5%) in the ciclopirox group, one of 109 (0.9%) in the placebo group in the first study and 10 of 118 (8.5%) in the ciclopirox group and zero of 117 (0%) in the placebo group in the second study.
Ciclopirox topical solution should be applied evenly to clean dry nails and 5 mm of the surrounding skin with the applicator brush daily at bedtime.
  More results at FactBites »


 
 

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