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Encyclopedia > Claforan
Cefotaxime chemical structure
Cefotaxime
Systematic (IUPAC) name
(6R,7R,Z)-3-(acetoxymethyl)-
7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-
8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-
2-carboxylic acid
Identifiers
CAS number 63527-52-6
ATC code J01DD01
PubChem 456256
DrugBank APRD00854
Chemical data
Formula C16H17N5O7S2
Mol. weight 455.47
Pharmacokinetic data
Bioavailability n/a
Metabolism hepatic
Half life 0.8–1.4 hours
Excretion 50-85% renal
Therapeutic considerations
Pregnancy cat.

B1 (Aust) IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The liver is an organ in vertebrates including humans. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... Motto: None Anthem: Advance Australia Fair Royal anthem: God Save the Queen Capital Canberra Largest city Sydney English (de facto 1) Government Constitutional monarchy (federal)  - Queen Elizabeth II  - Governor-General Michael Jeffery  - Prime Minister John Howard Independence from the UK   - Constitution 1 January 1901   - Statute of Westminster 11 December 1931...

Legal status

Schedule 4 (Aust) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... Motto: None Anthem: Advance Australia Fair Royal anthem: God Save the Queen Capital Canberra Largest city Sydney English (de facto 1) Government Constitutional monarchy (federal)  - Queen Elizabeth II  - Governor-General Michael Jeffery  - Prime Minister John Howard Independence from the UK   - Constitution 1 January 1901   - Statute of Westminster 11 December 1931...

Routes IV

Cefotaxime (INN) (IPA: [kɛfəˈtæksim, sɛfə-]) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various the trade names including Claforan (Sanofi-Aventis). In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... For information on how to read IPA transcriptions of English words see here. ... The cephalosporins, are a class of β-lactam antibiotics. ... Staphylococcus aureus - Antibiotics Test plate. ... Gram-positive bacteria are those that are stained dark blue or violet by gram staining, in contrast to Gram-negative bacteria, which are not affected by the stain. ... Gram-negative bacteria are those that do not retain crystal violet dye in the Gram staining protocol. ... Subgroups Actinobacteria Aquificae Bacteroidetes/Chlorobi Chlamydiae/Verrucomicrobia Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Nitrospirae Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Bacteria (singular: bacterium) are microscopic, unicellular organisms. ... Ceftriaxone (trade name Rocephin®) is a third-generation cephalosporin antibiotic. ... Sanofi-aventis (Euronext: SAN, NYSE: SNY), headquartered in Paris, France, is the worlds third largest company in the pharmaceutical industry behind Pfizer and GlaxoSmithKline but above Johnson & Johnson, Merck, AstraZeneca and Novartis. ...

Contents

Clinical use

The cephalosporins, are a class of β-lactam antibiotics. ...

Chemistry

The syn-configuration of the methoxyimino moiety confers stability to β-lactamase enzymes produced by many Gram-negative bacteria. Such stability to β-lactamases increases the activity of cefotaxime against otherwise resistant Gram-negative organisms. In chemistry, the methoxy prefix indicates the function group consisting of the methyl group and oxygen. ... An imine is a functional group or chemical compound containing a carbon-nitrogen double bond. ... Beta-lactamase is a type of enzyme (EC 3. ... Bacteria that are Gram-negative are not stained dark blue or violet by Gram staining, in contrast to Gram-positive bacteria. ...


See also

The cephalosporins, are a class of β-lactam antibiotics. ... Ceftriaxone (trade name Rocephin®) is a third-generation cephalosporin antibiotic. ...

External links

  • Link page to external chemical sources.

Cefotaxime Information Site

Cephalosporin Antibiotics (J01D) edit
First Generation:

Cefacetrile, Cefadroxil, Cefalexin, Cephaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole The cephalosporins, are a class of β-lactam antibiotics. ... Staphylococcus aureus - Antibiotics Test plate. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Cefacetrile (also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in G+ and G- bacterial infections. ... Cefadroxil is a broadspectrum antibiotic effective on both bactria GRAM +ve and GRAM -ve bactria. ... Cephalexin structure (racemic) Cefalexin (previously also British Approved Name Cephalexin) is a drug that is a member of the cephalosporin class of antibiotics. ... Cephaloglycin is a first generation cephalosporin antibiotic. ... Cefalotin (INN) (IPA: ) or cephalothin (USAN) (IPA: ) is a first-generation cephalosporin antibiotic. ... Cefapirin (or cephapirin) is a first-generation cephalosporin antibiotic. ... Cefazolin is an antibiotic in the chemical family of Cephalosporin. ... Cefradine (INN) or cephradine (former BAN) is a first generation cephalosporin antibiotic. ...

Second Generation:

Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam Cefaclor (brand name Raniclor®) is a 2nd generation cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections. ... Ceforanide is a second-generation cephalosporin antibiotic Crowle A, Sbarbaro J, May M (1988). ... Cefotiam is a second-generation cephalosporin antibiotic. ... Cefprozil, sometimes spelled cefproxil and sold under the brand name Cefzil, is a cephalosporin antibiotic. ... Cefuroxime is an cephalosporin antibiotic that has been widely available in the USA since 1977. ...

Third Generation:

Cefcapene , Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef Cefdinir is a semi-synthetic antibiotic in the third generation of the cephalosporin family of antibiotics. ... Cefixime is an oral third generation cephalosporin antibiotic. ... Cefmenoxime is a third-generation cephalosporin antibiotic. ... Cefpiramide is a third-generation cephalosporin antibiotic. ... Cefpodoxime is an oral third generation cephalosporin antibiotic. ... Ceftazidime is an antibiotic which eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, gynecological, and urinary tract infections. ... Ceftriaxone (trade name Rocephin®) is a third-generation cephalosporin antibiotic. ...

Fourth Generation:

Cefclidine, Cefepime, Cefetecol Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome This article needs to be cleaned up to conform to a higher standard of quality. ...



 
 

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