in medicine, renal clearance is the rate at which a substance is removed or cleared from the body by the kidneys
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The creatinine clearance test compares the level of creatinine in urine with the creatinine level in the blood, usually based on measurements of a 24-hour urine sample and a blood sample drawn at the end of the 24-hour period.
Because creatinine is found in stable plasma concentrations, is freely filtered and not reabsorbed, and is minimally secreted by the kidneys, creatinine clearance is used to estimate the glomerular filtration rate (GFR) -- the standard by which kidney function is assessed.
The creatinine clearance is an estimate of the glomerular filtration rate, that is, the volume of filtrate made by the kidneys per minute.
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