| Center for Developmental Biology (353 words) |
 | Furrowing movements are based on force generated by an actin-myosin system called the contractile ring, which is constructed beneath the plasma membrane of the cleavage furrow and requires the activity of the small GTPase, Rho. |
| We found that in cultured cells, Rho begins to accumulate at the cell cortex in the cleavage plane before furrowing is appreciable and remains localized at the cleavage furrow throughout cytokinesis. |
| Interestingly, in astral microtubule-disrupted cells, Rho accumulation at the putative furrow position was detected only at areas where the central spindle microtubules were closely located to the cell cortex, suggesting that both astral and central microtubules have the ability to recruit Rho to the furrow, even within the same cell. |
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