Clement Comer Clay (December 17, 1789–September 7, 1866) was the Democratic Governor of the U.S. state of Alabama from 1835 to 1837. He resigned when he was appointed to the United States Senate, where he served from June 19, 1837 until his resignation on November 15, 1841.

In 1836, Governor Clay signed a legislative act which chartered the third oldest Jesuit college in the United States, Spring Hill College in Mobile, Alabama, and gave it "full power to grant or confer such degree or degrees in the arts and sciences, or in any art or science as are usually granted or conferred by other seminaries of learning in the United States."