Clobazam is triazolobenzodiazepine, also known as a 1,5-benzodiazepine, meaning that its diazepine ring has its nitrogen atoms at the 1 and 5 positions instead of the usual 1 and 4. It is available in oral form only, due to its insolubility in water. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is a term used to describe a pharmacokinetic property of drugs, namely, the fraction of a dose which reaches the systemic circulation. ... The word plasma has a Greek root which means to be formed or molded (the word plastic shares this root). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... --212. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ...

It is used to control tonic-clonic, and complex partial seizures^[3]. This article is about the medical condition. ... Seizures (or convulsions) are temporary alterations in brain function expressing themselves into a changed mental state, tonic or clonic movements and various other symptoms. ...

Uses

Approved

Canada

Europe

India

• adjunctive therapy (used with other drugs) in epilepsy
• acute and chronic anxiety^[4]

Japan

Starting in 2000:

• treatment-resistant epilepsy^[5]

Unapproved/Investigational

Adverse Effects

Rare

• gelastic seizures^[6]

References

• Ochoa, Juan G. eMedicine - Antiepileptic Drugs: An Overview: GABA Receptor Agonists

End Notes

1. ^  PubChem Compound: Clobazam
2. ^  Parmeggiani A, Posar A, Sangiorgi S, Giovanardi-Rossi P. Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19. Brain Dev. 2004 Jan;26(1):63-6.
3. ^  Shimizu H, Kawasaki J, Yuasa S, Tarao Y, Kumagai S, Kanemoto K. Use of clobazam for the treatment of refractory complex partial seizures. Seizure. 2003 Jul;12(5):282-6.
4. ^  Aventis Pharma Ltd. India: Press Kits: Frisium
5. ^  Nakajima H. (A pharmacological profile of clobazam (Mystan), a new antiepileptic drug) Nippon Yakurigaku Zasshi. 2001 Aug;118(2):117-22.
6. ^  Iwasaki T, Miura H, Sunaoshi W, Hosoda N, Takei K, Katayama F.

(A case of intractable epilepsy showing frequent gelastic seizures by administration of clobazam) No To Hattatsu. 2003 Sep;35(5):406-10.