Clomethiazole
Systematic (IUPAC) name
5-(2-chloroethyl)-4-methyl-1,3-thiazole
Identifiers
CAS number	533-45-9
ATC code	N05CM02
PubChem	154087
Chemical data
Formula	C6H8ClNS
Mol. weight	161.653 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	? Image File history File links Clomethiazole. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
Legal status	POM(UK) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...
Routes	Oral

Clomethiazole (also called Chlormethiazole) is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... A sedative is a substance which depresses the central nervous system (CNS), resulting in calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ... Hypnotic drugs are a class of drugs that induce sleep, used in the treatment of severe insomnia. ... For the similarly-spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is a colorless compound with chemical formula C12H17N5O4S. It is soluble in water and insoluble in alcohol. ... A muscle relaxant is a drug which decreases the tone of a muscle. ... The anticonvulsants, sometimes also called antiepileptics, belong to a diverse group of pharmaceuticals used in prevention of the occurrence of epileptic seizures. ...

The drug acts on receptors in the brain known as GABA receptors, which cause the release of a chemical called GABA. GABA is a major inhibitory chemical in the brain involved in causing sleepiness and controlling anxiety and panics attacks. It acts by increasing the activity of GABA, thereby reducing the functioning of certain areas of the brain. This results in sleepiness, a decrease in anxiety and relaxation of muscles. It also inhibits a chemical called alcohol dehydrogenase that is responsible for breaking down alcohol in the body. This slows the rate of elimination of alcohol from the body, which helps to relieve the sudden effects of alcohol withdrawal in alcoholics. The GABA receptors are a group of receptors with γ-aminobutyric acid (GABA) as their endogenous ligand. ... Gamma-aminobutyric acid (usually abbreviated to GABA) is an inhibitory neurotransmitter found in the nervous systems of widely divergent species. ...

It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.

This medicine may cause drowsiness. If affected, do not drive or operate machinery. Alcohol should be avoided. Tolerance and dependence readily occur to this medicine. Tolerance means that less effect is achieved from the same dose. Dependence means that the patient finds it very difficult to stop using the medicine. Abrupt withdrawal may result in symptoms similar to those of sudden withdrawal of alcohol.

In the U.S, it is sold under the brand, Distraneurin® (AstraZeneca Pharmaceuticals) and in the U.K, Heminevrin® (AstraZeneca Pharmaceuticals). Another brand name include Nevrin® (in Romania). AstraZeneca PLC (LSE: AZN, NYSE: AZN), is a large Anglo-Swedish pharmaceutical company formed on 6 April 1999 by the merger of Swedish Astra AB and British Zeneca Group. ...

The Who drummer Keith Moon died due to overdose of this drug. Doctors said that there were at least 32 pills in his system with some remaining undissolved. The Who are an English rock band who first came to prominence in the 1960s and grew in stature to be considered one of the greatest rock n roll bands of all time[1][2][3]. Except for periods of retirement from 1983 to 1988 and from 1990 to 1995... Keith John Moon (August 23, 1946 – September 7, 1978) was the drummer of the rock group The Who. ...