D (USA) Image File history File links Clorazepate. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number chlorine, Cl, 17 Chemical series halogens Group, Period, Block 17, 3, p Appearance yellowish green Atomic mass 35. ... General Name, Symbol, Number potassium, K, 19 Chemical series alkali metals Group, Period, Block 1, 4, s Appearance brownish white Atomic mass 39. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The liver is the largest internal organ of the human body. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
Schedule IV(US) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ...
Clorazepate (marketed under the brand names Tranxene® and Tranxilium®) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... alprazolam 2mg tablets The benzodiazepines (pronounced , which are considered minor tranquilizers) are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. ... An anxiolytic is any drug or therapy used in the treatment of anxiety. ... The anticonvulsants, sometimes also called antiepileptics, belong to a diverse group of pharmaceuticals used in prevention of the occurrence of epileptic seizures. ... It has been suggested that this article or section be merged with hypnotic. ... In medicine, a muscle relaxant is a drug that causes skeletal muscle contraction to cease. ...
Clorazepate has been discontinued since February 2006 in the UK.
Indications
Clorazepate is used in the treatment of anxiety disorders and insomnia. It may also be prescribed as an anticonvulsant or muscle relaxant. Anxiety disorder is a blanket term covering several different forms of abnormal anxiety, fear, phobia and nervous condition, that come on suddenly and prevent pursuing normal daily routines. ... Insomnia is characterized by an inability to sleep and/or to be incapable of remaining asleep for a reasonable period. ... The anticonvulsants, sometimes also called antiepileptics, belong to a diverse group of pharmaceuticals used in prevention of the occurrence of epileptic seizures. ... A muscle relaxant is a drug which decreases the tone of a muscle. ...
Clorazepate is principally prescribed in the treatment of alcohol withdrawal and epilepsy, although it is also a useful anxiolytic because of its long half-life. The normal starting dosage range of clorazepate is 15-60 mg 2-4 x per day. Dosages as high as 90-120 mg per day may be used in the treatment of acute alcohol withdrawal. Clorazepate is available in 3.75, 7.5, and 15 mg capsules or tablets. Clorazepate SD (controlled release) is available in 11.25 and 22.5 mg tablets. Clorazepate SD is only prescribed when the patient has become adjusted to a certain dosage, and is taken once a day. Clorazepate is available in generic form. Clorazepate begins to act on the central nervous system within one or two hours, and its effects may be felt for an entire day or longer in some individuals. It is contraindicated for those with impaired renal or hepatic function. Clorazepate is listed under Schedule IV of the Controlled Substances Act. Clorazepate was approved for use in the United States by the Food and Drug Administration in 1972. Alcoholism is the consumption of, or preoccupation with, alcoholic beverages to the extent that this behavior interferes with the drinkers normal personal, family, social, or work life, and may lead to physical or mental harm. ... An anxiolytic is any drug or therapy used in the treatment of anxiety. ... A diagram showing the CNS: 1. ... The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 (21 USC 801 et sequitur). ... The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 (21 USC 801 et sequitur). ... This article or section is in need of attention from an expert on the subject. ...
Interactions
All sedatives are likely to magnify the effects of Tranxene® on the central nervous system. Cimetidine inhibits breakdown of clorazepate, and leads to increased levels of the drug in the system. Cimetidine is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. ...
Adinazolam, Alprazolam, Bromazepam, Brotizolam, Camazepam, Chlordiazepoxide, Cinolazepam, Clobazam, Clonazepam, Clorazepate, Clotiazepam, Cloxazolam, Diazepam, Doxefazepam, Estazolam , Ethyl loflazepate, Etizolam, Fludiazepam, Flunitrazepam, Flurazepam, Gidazepam, Halazepam, Ketazolam, Loprazolam, Lorazepam, Lormetazepam, Benzodiazepine tablets The benzodiazepines are a class of drugs with hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. ... Adinazolam is a benzodiazepine derivative. ... Alprazolam is a short-acting drug in the benzodiazepine class used to treat anxiety disorders and as an adjunctive treatment for depression. ... Bromazepam (marketed under brand names Compendium®, Creosedin®, Durazanil®, Lectopam®, Lexaurin®, Lexomil®, Lexotan®, Lexotanil®, Normoc®, Somalium®) is a drug which is a benzodiazepine derivative. ... Brotizolam (marketed under brand name Lendormin) is a drug which is a benzodiazepine derivative. ... Camazepam (marketed under the brand name Albego) is a drug which is a benzodiazepine derivative. ... Chlordiazepoxide (marketed under the trade name Librium®) is a hypnotic drug which is a benzodiazepine derivative. ... Cinolazepam is a drug which is a benzodiazepine derivative. ... Clobazam is triazolobenzodiazepine, also known as a 1,5-benzodiazepine, meaning that its diazepine ring has its nitrogen atoms at the 1 and 5 positions instead of the usual 1 and 4. ... Clonazepam (marketed by Roche under the trade-name Klonopin® in the United States and Rivotril® in Europe, Brazil and Canada) is a drug which is a benzodiazepine derivative. ... Clotiazepam (marketed under brand name Trecalmo) is a drug which is a benzodiazepine derivative. ... Cloxazolam (marketed under brand name Sepazon) is a drug which is a benzodiazepine derivative. ... Diazepam (IPA: ), marketed under brand names Valium, Stesolid, Seduxen, Bosaurin and Apozepam)[1] is a drug which is a benzodiazepine derivative. ... Doxefazepam (marketed under brand name Doxans) is a drug which is a benzodiazepine derivative. ... Estazolam (ProSom®) is a benzodiazepine commonly prescribed for short-term treatment of insomnia. ... Ethyl loflazepate (marketed under brand name Meilax®) is a drug which is a benzodiazepine derivative. ... Etizolam (marketed under brand name Sedekopan) is a drug which is a benzodiazepine derivative. ... Fludiazepam (marketed under the brand name Erispan) is a drug which is a benzodiazepine derivative. ... Flunitrazepam (formerly marketed under the trade name Rohypnol in North America, pronounced ) is a drug which is a benzodiazepine derivative. ... Flurazepam (marketed as Dalmane) is a benzodiazepine derivative which is used as a hypnotic. ... Gidazepam is a drug which is a benzodiazepine derivative. ... Halazepam is a benzodiazepine derivative. ... Ketazolam (marketed under brand names Anseren, Anxon, Contamex, Loftran, Marcen, Sedotime, Solatran, Unakalm) is a drug which is a benzodiazepine derivative. ... Loprazolam is a medicine of the Benzodiazepine family. ... Lorazepam (marketed under the brand names Ativan®, Temesta®, Tavor®) is a drug which is a benzodiazepine derivative. ... Lormetazepam (Noctamid®, Ergocalm®, Loramet®, also known as methyllorazepam, is a drug which is a benzodiazepine derivative. ...
Barbiturates:Barbexaclone, Metharbital, Methylphenobarbital, Phenobarbital, Primidone The anticonvulsants, sometimes also called antiepileptics, belong to a diverse group of pharmaceuticals used in prevention of the occurrence of epileptic seizures. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. ... Barbexaclone (marketed in Italy as Maliasin by Abbott Laboratories). ... Metharbital was marketed as Gemonil by Abbott Laboratories. ... Methylphenobarbital (also known as mephobarbital) is marketed in the US as Mebaral by Ovation. ... Phenobarbital (also phenobarbitone) (Luminal®) is a weak acid with the chemical formula C12H12N2O3. ... Primidone, is an anticonvulsant of the pyrimidinedione class whose active metabolites, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. ...
Hydantoins:Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin -- Oxazolidinediones:Ethadione, Paramethadione, Trimethadione Hydantoin, which is also known as glycolylurea, is a heterocyclic organic compound which can be thought of as a cyclic double-condensation reaction product of glycolic acid and urea. ... Ethotoin (marketed as Peganone® by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. ... Fosphenytoin (Cerebyx®, Parke-Davis) is a water-soluble phenytoin prodrug used in only in hospitals for the treatment of epileptic seizures. ... Mephenytoin (marketed as Mesantoin® by Novartis) is a hydantoin, used as an anticonvulsant. ... Phenytoin sodium (marketed as Dilantin® in the USA and as Epanutin® in the UK, by Parke-Davis, now part of Pfizer) is a commonly used antiepileptic. ... The following are oxazolidinediones: paramethadione trimethadione ethadione Categories: Pharmacology stubs | Antiepileptics ... Ethadione is an anticonvulsant medication in the oxazolidinedione family. ... Paramethadione is an anticonvulsant in the oxazolidinedione class. ... Trimethadione is an oxazolidinedione anticonvulsant. ...
Succinimides:Ethosuximide, Mesuximide, Phensuximide Succinimides are drugs that can be used as anticonvulsants. ... Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures. ... Mesuximide (or methsuximide) is an anticonvulsant medication. ... Phensuximide is an anticonvulsant in the succinimide class. ...
Benzodiazepines:Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam alprazolam 2mg tablets The benzodiazepines (pronounced , which are considered minor tranquilizers) are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. ... Clobazam is triazolobenzodiazepine, also known as a 1,5-benzodiazepine, meaning that its diazepine ring has its nitrogen atoms at the 1 and 5 positions instead of the usual 1 and 4. ... Clonazepam (marketed by Roche under the trade-name Klonopin® in the United States and Rivotril® in Europe, Brazil and Canada) is a drug which is a benzodiazepine derivative. ... Diazepam (IPA: ), marketed under brand names Valium, Stesolid, Seduxen, Bosaurin and Apozepam)[1] is a drug which is a benzodiazepine derivative. ... Lorazepam (marketed under the brand names Ativan®, Temesta®, Tavor®) is a drug which is a benzodiazepine derivative. ... Midazolam, (marketed under brand names Versed®, Hypnovel® and Dormicum®) is a drug which is a benzodiazepine derivative. ... Nitrazepam (marketed under the trade names Mogadon®, Nitredon®, Nilandron®) is a powerful hypnotic drug, which is a benzodiazepine derivative. ... To meet Wikipedias quality standards, this article or section may require cleanup. ...
Carboxamides:Carbamazepine, Oxcarbazepine, Rufinamide -- Fatty acid derivatives: Valpromide, Valnoctamide Carboxamides are drugs that can be used as anticonvulsants. ... Carbamazepine (sold under the brand-names Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Tegretol, Telesmin, Timonil) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. ... Oxcarbazepine (Marketed as Trileptal® by Novartis) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. ... Rufinamide is an anticonvulsant medication. ... In chemistry, especially biochemistry, a fatty acid is a carboxylic acid often with a long unbranched aliphatic tail (chain), which either saturated or unsaturated. ... Valpromide (dipropylacetamide, α-propylvaleramide, Diprozin) is a carboxamide derivative of valproic acid that is considered safer to use than either valproic acid or sodium valproate. ... Valnoctamide has been used in France as a tranquilizer and muscle relaxant since 1964[3] and as an anticonvulsant since starting in 1969 in Portugal. ...
Carboxylic acids:Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine -- GABA analogs:Gabapentin, Pregabalin, Progabide, Vigabatrin Structure of a carboxylic acid The 3D structure of the carboxyl group A space-filling model of the carboxyl group Carboxylic acids are organic acids characterized by the presence of a carboxyl group, which has the formula -(C=O)-OH, usually written as -COOH. In general, the salts and anions... Valproic acid or 2-Propylpentanoic acid is CH3CH2CH2CH(CH2CH2CH3)COOH . ... Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy. ... Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. ... Tiagabine is an anti-convulsive medication produced by Cephalon and marketed under the brand name Gabitril. ... Gaba may refer to: Gabâ or gabaa (Philippines), the concept of negative karma of the Cebuano people GABA, the gamma-amino-butyric acid neurotransmitter GABA receptor, in biology, receptors with GABA as their endogenous ligand Gaba 1 to 1, an English conversational school in Japan Marianne Gaba, a US model... Gabapentin (brand name: Neurontin®) was initially synthesized to mimic the structure of GABA for the treatment of epilepsy. ... Pregabalin (brand name: Lyrica®) is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. ... Progabide (INN) is an analog of gamma-aminobutyric acid used in the treatment of epilepsy. ... Vigabatrin is an anticonvulsant that inhibits the catabolism of GABA. It is an analog of GABA, but it is not a receptor agonist. ...
Others:-Monosaccharides:Topiramate -- Aromaticallylicalcohols:Stiripentol -- Ureas:Phenacemide, Pheneturide Monosaccharides are the simplest form of carbohydrates. ... Topiramate (brand name: Topamax®) is an anticonvulsant drug produced by Ortho-McNeil, a division of Johnson & Johnson. ... In chemistry, an aromatic molecule is one in which electrons are free to cycle around circular arrangements of atoms, which are alternately singly and doubly bonded to one another. ... An allyl group is an alkene hydrocarbon group with the formula H2C=CH-CH2-. It is made up of a vinyl group, CH2=CH-, attached to a methylene -CH2. ... In chemistry, an alcohol is any organic compound in which a hydroxyl group (-OH) is bound to a carbon atom of an alkyl or substituted alkyl group. ... Stiripentol (marketed as Diacomit by Laboratoires BIOCODEX) is an anticonvulsant drug used in the treatment of epilepsy. ... Urea is an organic compound of carbon, nitrogen, oxygen and hydrogen, with the formula CON2H4 or (NH2)2CO. Urea is also known as carbamide, especially in the recommended International Non-proprietary Names (rINN) in use in Europe. ... Phenacemide is an anticonvulsant of the urea class. ... Pheneturide (or ethylphenacemide) is an anticonvulsant medication. ...
Carbamates:Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam Carbamates are a group of organic compounds sharing a common functional group with the general structure -NH(CO)O-. More precisely the carbamate group is considered an amide group with an alkoxy or hydroxy functional group next to the carbonyl group. ... Emylcamate (marketed as Striatran® by Merck) is an anxiolytic and muscle relaxant. ... Felbamate (marketed as Felbamol by MedPointe) is an anticonvulsant drug used in the treatment of epilepsy. ... Meprobamate (marketed under the brand names Miltown® by Wallace Laboratories and Equanil® by Wyeth) is a carbamate derivative which is used as an anxiolytic drug. ... Flash point 3 °C R/S statement R: 11 20/21/22 35 S: 16 26 28 36/37 45 RTECS number UX9650000 Related compounds Related compounds pyrrole piperidine Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and... Levetiracetam (brand name: Keppra®) is an anticonvulsant medication used to treat epilepsy. ... Categories: Stub | Substances of the piracetam group ...
Sulfa drugs:Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates:Beclamide -- Aldehydes:Paraldehyde -- Bromides:Potassium bromide There are several sulphonamide-based groups of drugs. ... Acetazolamide, sold under the trade name Diamox®, is a carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, benign intracranial hypertension and altitude sickness. ... Ethoxzolamide (6-ethoxybenzothiazole-2-sulfonamide, alternatively known as Ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. ... Sulthiame (or Sultiame) is an anticonvulsant drug. ... Zonisamide (brand name Zonegran®) is an anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. ... The propionate (also propanoate) ion is C2H5COO− (propionic acid minus one hydrogen ion). ... Beclamide (marketed as Chloracon, Hibicon, Posedrine, Nydrane, Seclar, and other names) is a propionate and was used as a sedative and as an anticonvulsant. ... An aldehyde. ... Paraldehyde is the cyclic form of three acetaldehyde molecules (a trimer). ... A bromide is a phrase, or person who uses phrases, which have been used and repeated so many times as to become either insincere in their meaning, or seem like an attempt at trying to explain the obvious. ... Potassium bromide (KBr) is a salt, used as an anticonvulsant and a sedative in the 1800s. ...
Clorazepate is principally prescribed in the treatment of alcohol withdrawal and epilepsy, although it is also a useful anxiolytic because of its long half-life.
Clorazepate begins to act on the central nervous system within one or two hours, and its effects may be felt for an entire day or longer in some individuals.
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