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v. tr.
To cause transformation of (a liquid or sol, for example) into or as if into a soft, semisolid, or solid mass.
The platelets stimulate local activation of plasma coagulationfactors, leading to generation of a fibrinclot that reinforces the platelet aggregate.
In this manner, 11 plasma coagulationfactors were discovered: 6 in the "intrinsic" pathway (factors VIII, IX, XI, XII, prekallikrein, and high-molecular weight kininogen), 1 in the "extrinsic" pathway (factor VII), and 4 in the common pathway (factors II, V, X, and fibrinogen).
The importance of the GPIIb-GPIIIa in platelet activation and coagulation is demonstrated by the use of antibodies that block this receptor as anti-coagulants (e.g.
The coumarin drugs inhibit coagulation by inhibiting the vitamin K-dependent g-carboxylation reactions necessary to the function of thrombin, and factors VII, IX, and X as well as proteins C and S. These drugs act by inhibiting the reduction of the quinone derivatives of vitamin K to their active hydroquinone forms.
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