Codeinone is a strong Opiod. It is a intermediary substance in synthesises of semi-synthetic opioids, e.g. Naloxone and Naltrexone and Oxycodone. Opium is a narcotic drug which is obtained from the unripe seed pods of the opium poppy . ... Naloxone is a drug used to counter the effects of overdosing on opioids such as heroin and morphine. ... Naltrexone is an opioid receptor antagonist used in the management of alcohol dependence and opioid dependence. ... Oxycodone is a very powerful and potentially addictive opioid analgesic medication synthesized from thebaine. ...
Chemical structure
Codeinone can described as the methylether of morphinone: 3-Methyl-morphinone. Morphinone is a very strong Opiod. ...
Codeinone can be also described as the Ketone of Codeine: Codein-6-on A ketone is either the functional group characterized by a carbonyl group linked to two other carbon atoms or a compound that contains this functional group. ... Codeine ( INN) is an opioid used for its analgesic, antitussive and antidiarrhoeal properties. ...
A solution of codeinone dienol acetate (0.50 g, 1.48 mmol), formic acid (0.7 ml), hydrogen peroxide (0.43 g, 30%, 3.79 mmol), and water (1.4 ml) was heated at 43-44°C for 6 hr and cooled to rt.
Codeinone (6.0 g) with toluene (104 g) was added to a reaction flask equipped with a mechanical stirrer, thermocouple, Dean-Stark trap with condenser attached, and a nitrogen-inlet adapter.
Codeinone was prepared by oxidation of codeine phosphate or codeine.
Codeine itself is oxidized into codeinone, and the methyl ether of the enol form of this is the same as thebaine.
Moreover, since the action of acetic anhydride on codeinone makes it possible to isolate 3-methoxy-4:6 dihydroxyphenanthrene,[16] the respective positions of the phenol group and of the alcoholic hydroxyl must clearly be 3 and 6.
The constitution of these phenanthrene derivatives (morphol,[17] morphenol, thebaol,[18] etc.) was explained by Pschorr, who pioneered in the field of phenanthrene synthesis and succeeded in synthesizing the substitute phenanthrenes which have made it possible to identify by direct comparison most of the products of degradation of the morphine alkaloids.
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