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Biopharmaceutical glossaries & terminology (5904 words) |
 | Comparative genome mapping in the sequence- based era: early experience with human chromosome 7, JW Thomas et. |
| A genome map in which STSs are positioned relative to one another on the basis of the frequency with which they are separated by radiation-induced breaks. |
| In their paper, the International Human Genome Mapping Consortium describe how they constructed the first whole- genome physical map, how they created the templates from which the genome was sequenced and demonstrated how the map was essential for the accurate assembly of the human genome by the publicly funded effort. |
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Comparative genomic hybridization - Wikipedia, the free encyclopedia (433 words) |
| Comparative genomic hybridization (CGH) is a molecular-cytogenetic method for the analysis of copy number changes (gains /losses) in the DNA content of tumor cells. |
| The method is based on the hybridization of fluorescently labeled tumor (frequently Fluorescein - FITC) and normal DNA (frequently Rhodamine or Texas Red) to normal human metaphase preparations. |
| CGH is capable of detecting loss, gain and amplification of the copy number at the levels of chromosomes. |
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