| Animal Models of Psychiatric Disorders (9678 words) |
 | The evaluation of convergent validity is central to the approach described above in which a model is based theoretically upon a psychological process or behavioral dimension that is hypothesized to be affected in a psychiatric disorder. |
| Moreover, establishing the face validity of a model objectively is impossible, because claims for face validity of a model almost invariably involve subjective arbitrary arguments that are not necessarily accepted by all investigators in the field (see 87 for examples of models with proposed face validity). |
| The predictive validity in terms of pharmacological isomorphism of the model is indicated by the fact that pharmacological treatments clinically effective in depression, such as tricyclics, MAO inhibitors, atypical antidepressants, and electroconvulsive shock therapy are effective in reducing the behavioral and "physical" abnormalities seen in animals exposed to uncontrollable stress (87, 88). |
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