Coxsackie A virus is a cytolytic virus of the Picornaviridae family, a enterovirus (a group containing the polioviruses, coxsackieviruses, and echoviruses). There are 61 non-polio enteroviruses that can cause disease in humans, of them 23 are Coxsackie A viruses (6 are Coxsackie B viruses). Enterovirus are the second most common viral infectious agents in humans (after the rhinoviruses)
The virus was first documented in 1948, during an investigation into polio, and was named after the settlement in which it was found, Coxsackie, New York
Diseases
The most well known Coxsackie A disease is hand, foot and mouth disease (unrelated to foot and mouth disease), a common childhood illness, often produced by Coxsackie A16. In most cases infection is asymptomatic or causes only mild symptoms. In others, infection produces short-lived (7-10 days) fever and painful blisters in the mouth, on the palms and fingers of the hand, or on the soles of the feet. Other diseases include acute haemorrhagic conjunctivitis (A24 specifically), herpangina, and aseptic meningitis (both Coxsackie A and B viruses).
The virus was first documented in 1948 during an investigation into polio; it was named after the settlement in which it was found, Coxsackie, New York.
The most well known Coxsackie A disease is hand, foot and mouth disease (unrelated to foot and mouth disease), a common childhood illness, often produced by Coxsackie A16.
Herpangina, another coxsackievirus infection of the throat, causes blisters and ulcers on the soft palate, roof of the mouth, and tonsils (3).
The coxsackievirus mutates over long periods of time and is known to alter its pattern of behavior as well as its preferred tissue or organ target (7).
Coxsackievirus replication begins in the gastrointestinal tract, or the respiratory tract, and then progresses to the blood stream (5).
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