Craig C. Mello

Craig Cameron Mello (born October 19, 1960 in Worcester, Massachusetts), is one of the laureates of the 2006 Nobel Prize for Physiology or Medicine, along with Andrew Z. Fire, for the discovery of RNA interference. This research was conducted at the University of Massachusetts Medical School and published in 1998, where Mello is professor of Molecular Medicine. Image File history File links Craig-Mello. ... Image File history File links Craig-Mello. ... October 19 is the 292nd day of the year (293rd in leap years) in the Gregorian calendar. ... 1960 (MCMLX) was a leap year starting on Friday (the link is to a full 1960 calendar). ... The city of Worcester (pronounced ) is a city and the county town of Worcestershire in England, situated some 30 miles (48 km) southwest of Birmingham and 29 miles (47 km) north of Gloucester. ... Official language(s) English Capital Boston Largest city Boston Area  Ranked 44th  - Total 10,555 sq mi (27,360 km²)  - Width 183 miles (295 km)  - Length 113 miles (182 km)  - % water 13. ... Andrew Z. Fire Andrew Zachary Fire (born on April 27th 1959) is an American professor of pathology and of genetics at the Stanford University School of Medicine. ... The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system and is home to three schools: the #School of Medicine, the #Graduate School of Biomedical Sciences, the #Graduate School of Nursing; a thriving #biomedical research enterprise; and a range of #public...

Biography

Mello attended Fairfax High School (Fairfax, Virginia) and later received his BS from Brown University in 1982 and his PhD from Harvard University in 1990. He was a postdoctoral fellow at the Fred Hutchinson Cancer Research Center in the laboratory of Dr. James Priess. He is a professor of molecular medicine at the University of Massachusetts Medical School in Worcester, Massachusetts and has been on the faculty since 1994. Fairfax High School Fairfax High School is a public high school in Fairfax, Virginia. ... Brown University is a university located in Providence, Rhode Island. ... Harvard redirects here. ... The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system and is home to three schools: the #School of Medicine, the #Graduate School of Biomedical Sciences, the #Graduate School of Nursing; a thriving #biomedical research enterprise; and a range of #public... Nickname: The Heart of the Commonwealth, The City of the Seven Hills, Wormtown, Woo-town, Wortown (war-town), The City of Diners, Paris of the Eighties Settled: 1673 â€“ Incorporated: 1684 Zip Code(s): 01608 â€“ Area Code(s): 508 / 774 Official website: http://www. ...

Mello has been Howard Hughes Medical Institute investigator since 2000.^[1] The Howard Hughes Medical Institute (HHMI) is a United States non-profit medical research institute based in Chevy Chase, Maryland and originally founded by the aviator and engineer Howard Hughes in 1953. ...

Nobel prize

See also: RNAi

In 2006, Mello and Fire received the Nobel Prize for work that began in 1998, when Mello and Fire along with their colleagues (SiQun Xu, Mary Montgomery, Stephen Kostas, Sam Driver) published a paper ^[2] in the journal Nature detailing how tiny snippets of RNA fool the cell into destroying the gene's messenger RNA (mRNA) before it can produce a protein - effectively shutting specific genes down. In molecular biology, RNA interference (RNAi) is a mechanism in which the presence of small fragments of double-stranded RNA (dsRNA) whose sequence matches a given gene interferes with the expression of that gene. ... First title page, November 4, 1869 Nature is one of the oldest and most reputable scientific journals, first published on 4 November 1869. ... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ... The interaction of mRNA in a eukaryote cell. ...

The Nobel citation, issued by Sweden's Karolinska Institute, said: "This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information." The Karolinska Institute or Karolinska institutet is a medical university in Stockholm, Sweden. ...

Mello and Fire's research, conducted at the Carnegie Institution (Fire) and the University of Massachusetts Medical School (Mello), had shown that in fact RNA plays a key role in gene regulation. The BBC noted The Carnegie Institution of Washington (CIW) is a foundation established by Andrew Carnegie in 1902 to support scientific research. ... The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system and is home to three schools: the #School of Medicine, the #Graduate School of Biomedical Sciences, the #Graduate School of Nursing; a thriving #biomedical research enterprise; and a range of #public... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ... The British Broadcasting Corporation, invariably known as the BBC (and also informally known as the Beeb or Auntie) is the largest public broadcasting corporation in the world. ...

Professor Nick Hastie, director of the Medical Research Council's Human Genetics Unit, said the fact that the work had been recognised by the Nobel committee just eight years after it was published indicated just how important it had been. He said:"It is very unusual for a piece of work to completely revolutionise the whole way we think about biological processes and regulation, but this has opened up a whole new field in biology. Image File history File links Cquote1. ... Current MRC logo The Medical Research Council (MRC) is a UK organisation dedicated to promot[ing] the balanced development of medical and related biological research in the UK. // Organisation The MRC is one of eight Research Councils and is answerable to, although politically independent from, the Office of Science and... Professor Hastie said previously RNA had been thought to have very little role in regulating genes - in fact some thought it nothing more than a by-product. [3]

Image File history File links Cquote2. ...

Awards and honors

(By chronological year of award ^[4])

• Co-recipient (with Andrew Fire) of National Academy of Sciences Award in Molecular Biology in 2003
• Co-recipient (with Andrew Fire) of the Wiley Prize in the Biomedical Sciences from Rockefeller University in 2003
• Elected member National Academy of Sciences in 2005
• Co-recipient (with Andrew Fire) of Brandeis University's Lewis S. Rosenstiel Award for Distinguished Work in Medical Research in 2005
• Co-recipient (with Andrew Fire) of the Gairdner Foundation International Award in 2005
• Co-recipient (with Andrew Fire) of Massry Prize in 2005
• Co-recipient (with Andrew Fire) of the Paul Ehrlich and Ludwig Darmstaedter Prize in 2006
• Inaugural recipient of The Dr. Paul Janssen Award for Biomedical Research by Johnson & Johnson in 2006.
• Nobel Prize in 2006

President Harding and the National Academy of Sciences at the White House, Washington, DC, April 1921 The National Academy of Sciences (NAS) is a corporation in the United States whose members serve pro bono as advisers to the nation on science, engineering, and medicine. ... Rockefeller University is a private university focusing primarily on graduate education and research in the biomedical fields, located between 63rd and 68th street on York Avenue on the Upper East Side of Manhattan island in New York City, New York. ... President Harding and the National Academy of Sciences at the White House, Washington, DC, April 1921 The National Academy of Sciences (NAS) is a corporation in the United States whose members serve pro bono as advisers to the nation on science, engineering, and medicine. ... Brandeis University is a private university in Waltham, Massachusetts, United States. ... The Gairdner Foundation International Award is given annually at a special dinner to three to six people for outstanding discoveries or contributions to medical science. ... Paul Ehrlich Paul Ehrlich (March 14, 1854 – August 20, 1915) was a German scientist who won the 1908 Nobel Prize in Physiology or Medicine. ... Ludwig Darmstaedter (August 9, 1846, Mannheim - October 18, 1927, Berlin) was a German chemist and historian of science. ... Johnson & Johnson (NYSE: JNJ) is an international American pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. ... Nobel Prize medal. ...

External links

• Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, in Nature, via University of Massachusetts.
• Nobel prize news, via CNN.com

Nature is one of the oldest and most reputable general-purpose scientific journals, first published on November 4, 1869. ... This page is about the university system across Massachusetts. ...

References