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Encyclopedia > Cream (pharmaceutical)

A cream is a topical preparation usually for application to the skin. Creams for application to mucus membranes such as those of the rectum or vagina are also used. Creams may be considered pharmaceutical products as even cosmetic creams are based on techniques developed by pharmacy and unmedicated creams are highly used in a variety of skin conditions (dermatoses). In zootomy and dermatology, skin is an organ of the integumentary system made up of multiple layers of epithelial tissues that guard underlying muscles and organs. ... The mucous membranes (or mucosae; singular: mucosa) are linings of ectodermic origin, covered in epithelium, and are involved in absorption and secretion. ... The posterior aspect of the rectum exposed by removing the lower part of the sacrum and the coccyx. ... The vagina, (from Latin, literally sheath or scabbard ) is the tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles. ... Pharmaceutics is the discipline of pharmacy which deals with all facets of the process of turning a new chemical entity (NCE) into a medication able to be safely and effectively used by patients in the community. ... Bowl of Hygeia Pharmacy (from the Greek φάρμακον = drug) is the profession charged with ensuring the safe use of medication. ...


Creams are semi-solid emulsions, that is mixtures of oil and water. They are divided into two types: oil-in-water (O/W) creams which are composed of small droplets of oil dispersed in a continuous aqueous phase, and water-in-oil (W/O) creams which are composed of small droplets of water dispersed in a continuous oily phase. Oil-in-water creams are more comfortable and cosmetically acceptable as they are less greasy and more easily washed off using water. Water-in-oil creams are more difficult to handle but many drugs which are incorporated into creams are hydrophobic and will be released more readily from a water-in-oil cream than an oil-in-water cream. Water-in-oil creams are also more moisturising as they provide an oily barrier which reduces water loss from the stratum corneum, the outmost layer of the skin. A. Two immisicble liquids, not emulsified; B. An emulsion of Phase B dispersed in Phase A; C. The unstable emulsion progressively separates; D. The (purple) surfactant positions itself on the interfaces between Phase A and Phase B, stabilizing the emulsion An emulsion is a mixture of two immiscible (unblendable) substances. ... Oral medication A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... In chemistry, hydrophobic or lipophilic species, or hydrophobes, tend to be electrically neutral and nonpolar, and thus prefer other neutral and nonpolar solvents or molecular environments. ... The stratum corneum (the horny layer) is the outermost layer of the epidermis, and comprises the surface of the skin. ...

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Some uses of creams include:

Related topical preparations include ointments, lotions, liniments and gels. Sunscreen (also known as sunblock, suncream, suntan lotion) is a lotion, spray or other topical product that helps protect the skin from the suns ultraviolet radiation, and which reduces sunburn and other skin damage, ultimately leading to a lower risk of skin cancer. ... Emollients soften skin (and moisturisers add moisture). ... Oral medication A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... A local anesthetic is a drug that reversibly inhibits the propagation of signals along nerves. ... Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... An antibiotic is a drug that kills or slows the growth of bacteria. ... Something antifungal kills or inhibits the growth of fungus. ... An ointment is a viscous semisolid preparation used topically on a variety of body surfaces. ... A lotion is a non-viscous medicated topical preparation intended for application to unbroken skin. ... Liniment, from the Latin linere, to anoint, is a medicinal preparation meant for external use, but one that is thinner in consistency than an ointment. ... A gel (from the lat. ...


  Results from FactBites:
 
Viscoelastic Evaluation of Topical Creams Containing Microcrystalline Cellulose/Sodium Carboxymethyl Cellulose as ... (3387 words)
The purpose of this study was to examine the viscoelastic properties of topical creams containing various concentrations of microcrystalline cellulose and sodium carboxymethyl cellulose (Avicel® CL-611) as a stabilizer.
Products such as topical creams are designed for protracted residence on the skin and undergo a wide variety of stresses during removal from the container and application to the affected area.
Although the stress values were the same for the cream containing 2% Avicel and the commercial formulation, the commercial cream took more time to rebuild its structure at rest after shear, as shown by the greater thixotropic value of the commercial cream.
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