Cryoglobulinemia is the presence of abnormal proteins in the bloodstream which thicken or gel on exposure to cold. These proteins may be present in mycoplasmapneumonia, multiple myeloma, certain leukemias, primary macroglobulinemia, and some autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Cold can have the following meanings: Low temperatures, and/or the absence of heat Common cold, an infectious disease of the nose and throat Cold (band), a hard rock band Abbreviation for Computer Output to Laser Disk, see Enterprise Report Management (ERM) A James Bond novel, COLD by John Gardner... Species M. genitalium M. hominis M. pneumoniae etc. ... Pneumonia (the ancient Greek word for lungs) is defined as an infection involving the alveoli of the lungs. ... Multiple myeloma (also known simply as myeloma or plasma cell myeloma) is a hematological malignancy of plasma cells, the cells of the immune system that produce antibodies. ... Leukemia (leukaemia in Commonwealth English) is a group of blood diseases characterized by malignancies (cancer) of the blood-forming tissues. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ...
The disorder is the consequence of an immune-complex-type vasculitis as supported by: clinical features, analysis of the cryoglobulins, the usually depressed level of complement during the active phase of the: disease, and the deposition of immunoglobulins and complement in the lesions.
Mixed cryoglobulinemia was much more common in patients with hepatitis C virus infection (14 of 65 vs 1: of 110, P = 0.0001); it was not associated with the histologic type of lymphoma.
Cryoglobulinemia was detected in 1 patient: with LV and none in the control group.
Cryoglobulinemia may be associated with a particular disease (eg, lymphoproliferative disorder, autoimmune disease, infectious disease), or it may be an idiopathic form termed essential cryoglobulinemia.
Cryoglobulinemia may be underestimated based on the medical literature; Gorevic et al evaluated only 126 cases of cryoglobulinemia from 1960-1978 in their medical center in New York.
Morbidity secondary specifically to cryoglobulinemia may be significant, with the potential for arterial thrombosis or renal disease, or it may result in chronic symptoms that persist for years.
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