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Cancer research is research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure. Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues, either by direct growth into adjacent tissue through invasion or by implantation into distant sites by metastasis. ...
Cancer research ranges from epidemiology, molecular bioscience (bench research) to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy and hormone therapy, and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as immunotherapy and gene therapy. In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is a research study. ...
Intraoperative X-Ray of a Humerus fixated by Kirschner wires Surgery (from the Greek meaning hand work) is the medical specialty that treats diseases or injuries by operative manual and instrumental treatment. ...
Clinac 2100 C accelerator Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ...
Chemotherapy is the use of chemical substances to treat disease. ...
In medicine, hormone therapy is the use of hormones in medical treatment and covers various types of hormones including growth hormones and sex hormones. ...
The structure of insulin Biotechnology is a technology based on biology, especially when used in agriculture, food science, and medicine. ...
Immunotherapy is a form of medical treatment based upon the concept of modulating the immune system to achieve a therapeutic goal. ...
Gene therapy using an Adenovirus vector. ...
Genes involved in cancer
As the Cancer Genome Project stated in a 2004 review article1, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)". Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. Mutations in such genes can be used to classify the malignancy of a tumor. An oncogene is a modified gene that increases the malignancy of a tumor cell. ...
A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ...
In later stages, tumors can develop a resistance to cancer treatment. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success. Genes and protein products that have been identified by at least two independent publications as being involved in cancer are: ABI1, ABL2, ACSL6, AF1Q, AF5Q31, AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC, GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1 based on a study by M. R Straton and co-workers " A census of human cancer genes". Akt, also known as protein kinase B (PKB) is an important molecule in mammalian cellular signaling. ...
Cyclins are a family of proteins involved in the progression of cells through the cell cycle. ...
Cyclin-dependent kinase is a protein kinase involved in regulation of the cell cycle. ...
Catenins are cadherin-binding molecules in mammalian cells. ...
In biology, histones are the chief proteins of chromatin. ...
HRAS is a human gene that provides instructions for making a protein that is involved in cell division. ...
c-Myc is a mammalian transcription factor belonging to the bHLH (basic Helix Loop Helix)_Leucine Zipper family. ...
PPAR gamma In cell biology, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor isoforms that exist across biology. ...
RB1 (retinoblastoma 1 (including osteosarcoma)) is a human gene that belongs to a class of genes known as tumor suppressor genes. ...
STAT protein The Signal Transducers and Activator of Transcription (STAT) protein regulates many aspects of cell growth, survival and differentiation. ...
TP53 (tumor protein p53 (Li-Fraumeni syndrome)) is a gene that provides instructions for making a protein called tumor protein p53. ...
To meet Wikipedias quality standards, this article or section may require cleanup. ...
See also The Ludwig Institute for Cancer Research is a global non-profit medical research institute that undertakes clinical research into cancer and early-phase clinical trials. ...
UD Agent The United Devices Cancer Research Project, is one of several distributed computing projects that have been operated on the website by United Devices. ...
NCI-designated Cancer Centers are a group of approximately 60 cancer research institutions in the United States supported by the National Cancer Institute. ...
References - Note 1: Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman, N, Stratton MR (2004). "A census of human cancer genes". Nature Reviews Cancer 4: 177-83. PMID 14993899.
A cover of Nature Reviews Cancer Nature Reviews Cancer is a highly respected cancer biology journal with a very high Impact Factor of 36. ...
External links - Scientific cancer research (UK)
- Cancer Genome Project @ The Sanger Institute
- Cancer Genome Anatomy Project @ The NIH
- Biology of Blood and Marrow Transplantation
- http://www.oncophyta.org/info/ - link given by Balasubramanian Chennai
- CBC Digital Archives – Cancer Research: The Canadian Quest for a Cure
- Academic Clinical Oncology & Radiobiology Research NetworkRevitalising radiotherapy research in the UK.
| Tumors (and related structures), Cancer, and Oncology edit | | Benign - Premalignant - Carcinoma in situ - Malignant Topography: Anus - Bladder - Bone - Brain - Breast - Cervix - Colon/rectum - Duodenum - Endometrium - Esophagus - Eye - Gallbladder - Head/Neck - Liver - Larynx - Lung - Mouth - Pancreas - Penis - Prostate - Kidney - Ovaries - Skin - Stomach - Testicles - Thyroid Tumor (American English) or tumour (British English) originally means swelling, and is sometimes still used with that meaning. ...
Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues, either by direct growth into adjacent tissue through invasion or by implantation into distant sites by metastasis. ...
Oncology is the medical subspecialty dealing with the study and treatment of cancer. ...
Benign can refer to any medical condition which, untreated or with symptomatic therapy, will not become life-threatening. ...
A premalignant condition is a disease, syndrome, or finding that, if left untreated, may lead to cancer. ...
Carcinoma in situ is present when a tumor has been detected that has the characteristics of malignancy but has not invaded other tissues. ...
In medicine, malignant is a clinical term that is used to describe a clinical course that progresses rapidly to death. ...
Anal cancer is a distinct entity from the more common colorectal cancer. ...
Bladder cancer refers to any of several types of malignant growths of the urinary bladder. ...
Bone tumor is an inexact term, which can be used for both benign and malignant abnormal growths found in bone, but is most commonly used for primary tumors of bone, such as osteosarcoma (or osteoma). ...
A brain tumor is any intracranial tumor created by abnormal and uncontrolled cell division, normally either found in the brain itself (neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells), lymphatic tissue, blood vessels), in the cranial nerves (myelin-producing Schwann cells), in the brain envelopes (meninges), skull, pituitary and pineal gland...
Breast cancer is cancer of breast tissue. ...
Cervical cancer is a malignancy of the cervix. ...
Colorectal cancer, also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. ...
This article needs more context around or a better explanation of technical details to make it more accessible to general readers and technical readers outside the specialty, without removing technical details. ...
Endometrial cancer involves cancerous growth of the endometrium (lining of the uterus). ...
Esophageal cancer is malignancy of the esophagus. ...
Cancers can affect the eye. ...
Bold textA more uncommon cancer predominate in females, if found early on before symptoms, can be cured by removing Gallbladder, most often it is found after symptoms occur (abdominal pain, Jaundice) and has spread to other organs such as liver and the outlook at this point is poor. ...
Head and neck cancers are malignant growths originating in the lip and oral cavity (mouth), nasal cavity, pharynx, larynx, thyroid, paranasal sinuses, salivary glands and cervical lymph nodes of the neck. ...
Hepatocellular carcinoma (HCC, also called hepatoma or liver cancer) is a primary malignancy (cancer) of the liver. ...
Cancer of the larynx also may be called laryngeal cancer. ...
Lung cancer is a cancer of the lungs characterized by the presence of malignant tumours. ...
Oral cancer is any cancerous tissue growth located in the mouth. ...
Pancreatic cancer (also called cancer of the pancreas) is a malignant tumour within the pancreatic gland. ...
Penile cancer is a malignant growth found on the skin or in the tissues of the penis, usually originating in the glans and/or foreskin. ...
Prostate cancer is a disease in which cancer develops in the prostate, a gland in the male reproductive system. ...
Renal cell carcinoma, also known by a gurnistical tumor, is the most common form of kidney cancer arising from the renal tubule. ...
Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries). ...
Skin cancer is a malignant growth on the skin, which can have many causes, including repeated severe sunburns or long-term exposure to the sun. ...
Stomach cancer (also called gastric cancer) can develop in any part of the stomach and may spread throughout the stomach and to other organs, particularly the esophagus, small intestine. ...
Testicular cancer is a type of cancer that develops in the testicles, a part of the male reproductive system. ...
Morphology: Papilloma/carcinoma - Choriocarcinoma - Adenoma/adenocarcinoma - Soft tissue sarcoma - Melanoma - Fibroma/fibrosarcoma - Metastasis - Lipoma/liposarcoma - Leiomyoma/leiomyosarcoma - Rhabdomyoma/rhabdomyosarcoma - Mesothelioma - Angioma/angiosarcoma - Osteoma/osteosarcoma - Chondroma/chondrosarcoma - Glioma - Lymphoma/leukemia Papilloma refers to a benign epithelial tumor. ...
In medicine, carcinoma is any cancer that arises from epithelial cells. ...
Choriocarcinoma is a rare cancer of the placenta, curable by chemotherapy. ...
Adenoma refers to a collection of growths (-oma) of glandular origin. ...
In medicine, carcinoma is any cancer that arises from epithelial cells. ...
Malignant (cancerous) tumors that develop in soft tissue are called sarcomas, a term that comes from a Greek word meaning fleshy growth. ...
This article or section does not cite its references or sources. ...
Soft Fibroma (fibroma molle). ...
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
A lipoma is a common, benign tumor composed of fatty tissue. ...
This article needs to be cleaned up to conform to a higher standard of quality. ...
A leiomyoma (plural is leiomyomata) is a benign smooth muscle neoplasm that is not premalignant. ...
A sarcoma is a cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. ...
A rhabdomyoma is a benign tumor of muscle. ...
A rhabdomyosarcoma is a type of cancer, specifically a sarcoma (cancer of connective tissues), in which the cancer cells arise from skeletal muscle. ...
Angiomas are benign tumors that are made up of small blood vessels. ...
Angiosarcoma is a rare, malignant tumor consisting of endothelial and fibroblastic tissue that proliferates and eventually surrounds vascular channels. ...
An osteoma is a new piece of bone growing on another piece, typically the skull. ...
Osteosarcoma is a common primary bone cancer. ...
A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. ...
A chondrosarcoma is a cancer of the cartilage. ...
A glioma is a type of primary central nervous system (CNS) tumor that arises from glial cells. ...
Lymphoma is a variety of cancer that originates in the lymphatic system. ...
Leukemia or leukaemia (see spelling differences) is a cancer of the blood or bone marrow characterized by an abnormal proliferation of blood cells, usually white blood cells (leukocytes). ...
Treatment: Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment Intraoperative X-Ray of a Humerus fixated by Kirschner wires Surgery (from the Greek meaning hand work) is the medical specialty that treats diseases or injuries by operative manual and instrumental treatment. ...
Chemotherapy is the use of chemical substances to treat disease. ...
Clinac 2100 C accelerator Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ...
Cancer Immunotherapy is the use of the immune system to reject cancer. ...
Experimental cancer treatments are medical therapies intended or claimed to treat cancer (see also tumor) by improving on, supplementing or replacing conventional methods (surgery, chemotherapy, radiation, and immunotherapy). ...
Related structures: Cyst - Dysplasia - Hamartoma - Neoplasia - Nodule - Polyp - Pseudocyst This is an article about cysts in the body. ...
Dysplasia (latin for bad form) is an abnormality in the appearance of cells indicative of an early step towards transformation into a neoplasia. ...
A hamartoma is an abnormal growth of normal cells. ...
Neoplasia (literally: new growth) is abnormal, disorganized growth in a tissue or organ, usually forming a distinct mass. ...
In medicine, a nodule refers to a small aggregation of cells. ...
Polyp of sigmoid colon as revealed by colonoscopy. ...
A pseudocyst is a pathological collection of fluid. ...
Misc: Tumor suppressor genes/oncogenes - Staging/grading - Carcinogenesis/metastasis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ...
An oncogene is a modified gene that increases the malignancy of a tumor cell. ...
The stage of a cancer is a descriptor (usually numbers I to IV) of how much the cancer has spread. ...
In pathology, Grading is a measure of the progress of tumors. ...
Cancers are caused by a series of mutations. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
In pathology, a carcinogen is any substance or agent that promotes cancer. ...
A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. ...
The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. ...
This is a list of terms related to oncology. ...
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