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Encyclopedia > Cyclazocine
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Cyclazocine is a mixed opiate agonist-antagonist.


Use


Research into the use of cyclazocine for the treatment of Bipolar patients with depression was undertaken by Fink and colleagues (1970). It showed that 8 out of 10 patients experienced moderate improvement.


Dosage Dosages of 1-3mg were administered in the tests


  Results from FactBites:
 
UNODC - Bulletin on Narcotics - 1970 Issue 1 - 001 (5964 words)
Cyclazocine is a powerful specific opiate antagonist and may properly be called anti-narcotic and a blocker of morphine-like effects.
Cyclazocine tolerance does not block the effects of non-opiates, barbiturates, amphetamines, etc. and a switch to them is possible.
The use of cyclazocine as a deterrent requires first complete withdrawal of the narcotic on which the patient is dependent, dose supervision and careful build up of the dose to the tolerance level.
Medscape MEDLINE search: Cyclazocine (1089 words)
The effects of cyclazocine and hydromorphone on spontaneous and laboratory cigarette smoking were compared in a double-blind, placebo-controlled, crossover study.
The cardiovascular effects of intravenous pentazocine and cyclazocine in dogs were studied under conscious, curarized-conscious (paralyzed by gallamine), and anesthetized states.
In response to the unexpectedly high affinity for opioid receptors observed in a novel series of cyclazocine analogues where the prototypic 8-OH was replaced by a carboxamido group, we have prepared the corresponding 3-CONH(2) analogues of morphine and naltrexone.
  More results at FactBites »


 

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