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Cyclin dependent kinase - definition of Cyclin dependent kinase in Encyclopedia (107 words) |
 | Cyclin-dependent kinase is a protein kinase involved in regulation of the cell cycle. |
| A cyclin-dependent kinase is activated by association with a cyclin forming a cyclin-dependent kinase complex. |
| Timothy Hunt, and Paul M. Nurse won the 2001 Nobel Prize in Physiology or Medicine for their discovery of cyclin and cyclin-dependent kinase, central molecules in the regulation of the cell cycle. |
| CDK6 - Cell division protein kinase 6 (5142 words) |
| Cyclin D1 expression was absent despite high levels of CDK4 and CDK6, and the CKI p27 was expressed in chondrocytes, osteoclasts, and at lower levels in osteoblasts. |
| In contrast to p21 and p27 whose interaction with CDK subunits is dependent on or stimulated by the cyclin subunit, the interaction of p19 and p18 with CDK6 is hindered by the cyclin protein. |
| Cyclins D1, D2 and D3 preferentially associate with two closely related members of the cyclin-dependent kinase family, Cdk4 and Cdk6 and the various complexes are each capable of phosphorylating the retinoblastoma gene product (pRb), at least in vitro. |
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