FACTOID # 39: The eight most developed countries all speak Germanic languages.
 
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Encyclopedia > DC SIGN

A C-type lectin receptor present mainly on myeloid and pre-plasmacytoid dendritic cells that mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens. This molecule is involved in initial stages of HIV infection as the HIV gp120 molecule causes co-internalization of the DC-SIGN molecule and HIV virion. The dendritic cell then migrates to the cognate lymphoid organ, whereupon recycling of the DC-SIGN/HIV virion complex to the cell periphery facilitates HIV infection of T cells by interaction between DC-SIGN and ICAM-3.


CD209


  Results from FactBites:
 
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells -- Tassaneetrithep et al. 197 (7): 823 -- The ... (5574 words)
(9) that DCs and not monocytes or macrophages are preferentially
DCs or THPs were pretreated with an anti–DC-SIGN mAb (clone 120612) or a matched isotype control and exposed to DV for 2 h.
of heterotypic DV infection, is not observed in DCs (10).
DC Vote (492 words)
Founded in 1998, DC Vote is an educational and advocacy organization whose mission is to secure full voting representation in Congress for the residents of the District of Columbia.
DC Vote's four volunteer committees give supporters in DC and across the country the opportunities they are looking for to help move our issue.
DC Vote is also leading the effort to educate members of Congress and their staff.
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