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BACTERIAL PRIMASE HOME PAGE (1698 words) |
 | Primase is required because DNA polymerases cannot initiate polymer synthesis; DNA polymerases can only elongate polymers that have already been initiated. |
| The ts mutants that arrest DNA synthesis immediately after raising the temperature are called quick-stop mutants and are thought to indicate that the gene plays a role in the elongation phase of DNA replication. |
| The bacterial primases motif is the hinge polypeptide between subdomains 1 and 2 and there is a Hydrogen bond between Arg146 from motif 2 in sub1 and Asp347 from motif 6 in sub2 may stabilize the subdomain 1-2 interface. |
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