Darier's disease is a genetic disorder discovered by French dermatologist Ferdinand-Jean Darier. Darier's disease is known because of dark crusty patches on the skin, sometimes containing pus. The crusty patches are also known as keratotic papules and also called keratosis follicularisis. The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ... The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... Dermatology (from Greek derma, skin) is a branch of medicine dealing with the skin and its appendages (hair, nails, sweat glands etc). ... Ferdinand-Jean Darier Darier Jean Ferdinand (b. ... Pus is a whitish-yellow or yellow substance produced during inflammatory responses of the body that can be found in regions of pyogenic bacterial infections. ...

Mutations in the gene ATP2A2 cause Darier's disease. Family members with confirmed identical ATP2A2 mutations can exhibit differences in the clinical severity of disease, suggesting that other genes or environmental factors affect the expression of Darier's disease. With the discovery of the ATP2A2 gene, performing genetic tests to confirm the diagnosis of Darier's disease is now possible.

The disease is hereditary and dominant. It affects both men and women and is not contagious. The disease often starts during or later than the teenage years, typically by the third decade. The symptoms of the disease are thought to be caused by an abnormality in the desmosome-keratin filament complex leading to a breakdown in cell adhesion. This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... In genetics, the term dominant gene refers to the allele that causes a phenotype that is seen in a heterozygous genotype. ...

It most commonly affects the chest, neck, back, ears, forehead, and groin, but may involve other body areas. The rash associated with Darier's disease often has a distinct odor. The rash can be aggravated by heat, humidity, and exposure to sunlight.

This is one of the three skin diseases discovered by Darier.

There are ways to control darier without the use of medications such as listed on the links below.

Being a sufferer of this disease I found that using Soap free products when showering helps clear the skin as they don't remove the natural moisture in the skin. Vitamin E is another good thing to use on affected areas. For washing hair as it is often found very dominant in the scalp and forehead areas Johnsons Soap Free Baby Shampoo works best.

Soap Free products available that I have tested most of which are baby care products seem to work better than products designed for Adults.

Johnsons Top To Toe Baby Bath (Available To Purchase Online www.johnsonbaby.com) Curash Soap Free Baby Bath (Australian Product www.curash.com.au)

External links

• Dermnetnz
• Photos
• eMedicine
• OMIM