David Henry Gambrell (born December 20, 1929) is a politician from the U.S. state of Georgia.

Gambrell was born in Atlanta, Georgia, graduating from Davidson College and serving in the reserves of the United States Army. Gambrell directed the National Legal Aid and Defenders Association from 1965 to 1971. Gambrell also served as the head of the Georgia Democratic Party.

Gambrell was appointed to the United States Senate by Governor Jimmy Carter on February 1, 1971 on the death of Richard B. Russell, Jr.. Gambrell was unsuccessful in his bid for a full term, losing to Sam Nunn in the primary. Gambrell returned to practicing law and has endorsed Republican George W. Bush in the 2004 Presidential election.