In general usage, de novo is a Latin expression meaning 'afresh', 'anew', 'beginning again'.
In Banking, a de novo bank is defined as a state member bank that has been in operation for five years or less. Commercial banks that have been in existence for five years or less and convert to Fed membership are also subject to the de novo bank application and supervision standards.
In Bioinformatics, de novo is a form of sequencing, as in "peptide de novo sequencing".
In Biochemistry, de novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to their being recycled after partial degradation. For example, de novo synthesis of nucleotides, as opposed to the salvage pathway.
In Financial terminology, numbers reported by newly founded companies (especially the financial services industry) are qualified as "de novo," to distinguish them from older companies. For example, "growth de novo" means growth of newly started companies.
In Law, the expression trial de novo literally means "new trial". It is most often used in certain legal systems that provide for one form of trial, then another if a party remains unsatisfied with the decision.
In Medicine and genetics a de novo mutation is one which neither parent possessed or transmitted. It first appeared in the DNA of the affected individual.
Could someone write about De Novo Transplants?
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In law, the expression trialdenovo literally means "new trial".
If the determination made by a lower body is overturned, it may be renewed denovo in the review process (this is usually before it reaches the court system).
In order to protect the individual's rights against double jeopardy ordering a trial"denovo" is often the exclusive right of an appealjudge.
Denovo MGN was seen in 30 biopsy specimens from 21 patients (about 2%), of whom 10 had received immunosuppressive treatment without and 11 with cyclosporine.
Denovo MGN was diagnosed by biopsy 62.7 +/- 44.4 mo. after transplantation; its incidence increased significantly with time (from 0% to 5.3% over 8 years; 95% confidential interval: 1.7-8%).
Denovo MGN is a late, often asymptomatic, complication of initially well tolerated grafts and is neither prevented by cyclosporine treatment nor reversed by further steroid medication.
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