In general usage, de novo is a Latin expression meaning 'afresh', 'anew', 'beginning again'.

• In USA Banking, a de novo bank is defined as a state member bank that has been in operation for five years or less. Commercial banks that have been in existence for five years or less and convert to Fed membership are also subject to the de novo bank application and supervision standards.

• In Bioinformatics, de novo is a form of sequencing, as in "peptide de novo sequencing".

• In Biochemistry, de novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to their being recycled after partial degradation. For example, de novo synthesis of nucleotides, as opposed to the salvage pathway.

• In Financial terminology, numbers reported by newly founded companies (especially the financial services industry) are qualified as "de novo," to distinguish them from older companies. For example, "growth de novo" means growth of newly started companies.

• In Law, the expression trial de novo literally means "new trial". It is most often used in certain legal systems that provide for one form of trial, then another if a party remains unsatisfied with the decision. "De Novo" can also be a standard of review in appellate law, signifying that the reviewing court can examine all of the trial court's findings of evidence and law.

• In Medicine and genetics a de novo mutation is one which neither parent possessed or transmitted. It first appeared in the DNA of the affected individual.

• In Marketing and Advertising de novo means "again, but in a different way" and is linked to guerrilla and grass roots marketing campaigns.

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