Decorin is a proteoglycan on average 90 - 140 kilodaltons (kD) in size. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either Chondroitin Sulfate (CS) or Dermatan Sulfate (DS). Decorin is found in the extracellular matrix. Decorin's name is a derivative of both the fact that it "decorates" collagen, and that it interacts with the "d" and "e" bands. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor EGFR and transforming growth factor-beta (TGF-beta). In some publications, decorin has enhanced the bioactivity of TGF-beta 1, in other publications, TGF-beta 1's bioactivity has been inhibited. Because of this, it is believed the primary function of decorin lies in certain aspects of regulation during the cell cycle. Hugo is a masculine name. ... Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 12 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell. ... Fibronectin is a high molecular weight glycoprotein containing about 5% carbohydrate that binds to receptor proteins that span the cells membrane, called integrins. ... Tropocollagen triple helix. ... Within a protein, a structural domain (domain) is an element of overall structure that is self-stabilizing and often folds independently of the rest of the protein chain. ... A taxon (plural taxa), or taxonomic unit, is a grouping of organisms (named or unnamed). ... Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ... Phyla Subkingdom Parazoa Porifera (sponges) Subkingdom Agnotozoa Placozoa Orthonectida Rhombozoa Subkingdom Metazoa Radiata Cnidaria Ctenophora - Comb jellies Bilateria Protostomia Acoelomorpha Platyhelminthes - Flatworms Nemertina - Ribbon worms Gastrotricha Gnathostomulida - Jawed worms Micrognathozoa Rotifera - Rotifers Acanthocephala Priapulida Kinorhyncha Loricifera Entoprocta Nematoda - Roundworms Nematomorpha - Horsehair worms Cycliophora Mollusca - Mollusks Sipuncula - Peanut worms Annelida - Segmented... Phylum (plural: phyla) is a taxon used in the classification of animals, adopted from the Greek phylai the clan-based voting groups in Greek city-states. ... There are about 210 types of human cells. ... In zootomy and dermatology, skin is an organ of the integumentary system made up of multiple layers of epithelial tissues that guard underlying muscles and organs. ... The lungs flank the heart and great vessels in the chest cavity. ... The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... It has been suggested that this article or section be merged into Muscular system. ... Cartilage is a type of dense connective tissue. ... A ligament is a short band of tough fibrous connective tissue composed mainly of long, stringy collagen fibres. ... In cell biology, molecular biology and related fields, the word extracellular means outside the cell. It is used in contrast to intracellular (inside the cell). ... Covalently bonded hydrogen and carbon in a molecule of methane. ... A disease or medical condition is an abnormality of the body or mind that causes discomfort, dysfunction, distress, or death to the person afflicted or those in contact with the person. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Proteoglycans represent a special class of glycoprotein that are heavily glycosylated. ... The unified atomic mass unit (u), or dalton (Da), is a small unit of mass used to express atomic masses and molecular masses. ... Glycosaminoglycans (GAGs) are long unbranched polysaccharides, made up of repeating disaccharides that may be sulphated (e. ... In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell. ... Tropocollagen triple helix. ... Fibronectin is a high molecular weight glycoprotein containing about 5% carbohydrate that binds to receptor proteins that span the cells membrane, called integrins. ... Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis. ... Epidermis could refer to: In plants, the outermost layer of cells covering the leaves and young parts of a plant is the epidermis. ... Growth factor is a protein that acts as a signaling molecule between cells (like cytokines and hormones) that attaches to specific receptors on the surface of a target cell and promotes differentiation and maturation of these cells. ... Receptor may refer to: In telecommunication, a receiver. ... Rich in anti-oxidents, TGF beta is a welcome addition to the female diet. ... The cell cycle, or cell-division cycle (CDC), is the series of events in a eukaryotic cell between one cell division and the next. ...

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