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Thyroid Metabolism (12310 words) |
 | Within the liver, type I deiodinase activity may either result in formation of T3, subsequent to the removal of an iodine from the outer phenolic ring by a selenium-dependent hepatic 5'-deiodinase enzyme, or it can remove iodine from the inner tyrosyl ring by 5-deiodinase resulting in the formation of rT3. |
| The 20-fold increase in deiodinase activity secondary to acute cold exposure in rats was impaired in selenium deficiency. |
| Since zinc is not a cofactor in hepatic type I-deiodinase enzyme, the nature of zinc's influence on aspects of peripheral metabolism in animals and humans remains unclear. |
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Deiodinase (50 words) |
| Deiodinase is an enzyme important in the action of thyroid hormones. |
| In the tissues, deiodinase converts the prohormone[?] thyroxine to the active hormone triiodothyronine[?] by the removal of an iodine atom. |
| Deiodinases are unusual in that the enzyme contains selenium, in the form of an otherwise rare amino acid selenocysteine |
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