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Deleterious means hurtful, injurious or harmful to living things "deleterious chemical additives" or "deleterious genes"
Deng and Lynch (1, 2) proposed to characterize deleterious genomic mutations from changes in the mean and genetic variance of fitness traits upon selfing in outcrossing populations.
Estimates of the genomic mutation rate to mildly deleterious alleles (U) are crucial to testing theories for the evolution of sex (3-6), mate choice (5, 7, 8), outbreeding mechanisms (7), diploidy (9), and the accelerated extinction rate of small populations (10-13).
In order to correctly characterize deleterious genomic mutations from natural populations (1, 2, 18, 27), this assumption needs to be examined closely-a task that is being actively pursued (53).