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Encyclopedia > Delta catenin
catenin (cadherin-associated protein), delta 1
Identifiers
Symbol CTNND1 CTNND
HUGO 2515
Entrez 1500
OMIM 601045
RefSeq NM_001331
UniProt O60716
Other data
Locus Chr. 11 q12.1
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
Symbol CTNND2
HUGO 2516
Entrez 1501
OMIM 604275
RefSeq NM_001332
UniProt Q9UQB3
Other data
Locus Chr. 5 p15.2

Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 11 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ... Familial Alzheimers disease (FAD) is an uncommon form of Alzheimers disease that comes on earlier in life, defined as before the age of 65 (usually between 30 and 65 years of age) and is inherited in an autosomal dominant fashion. ...


While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.[4] The wnt signalling pathway is a network of proteins that has been implicated in embryogenesis and cancer. ... NF-κB, or Nuclear Factor kappa B, is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. ...


References

  1. ^ I. Israely, R. M. Costa, C. w. Xie, A. J. Silva, K. S. Kosik and X. Liu "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction" in Current Biology (2004) Volume 14, pages 1657-1663. Entrez PubMed 15380068
  2. ^ M. E. Rubio, C. Curcio, N. Chauvet and J. L. Bruses. "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1" in Molecular and Cellular Neurosciences (2005) Volume 4, pages 611-623. Entrez PubMed 16456928
  3. ^ J. L. Teo, H. Ma, C. Nguyen, C. Lam and M. Kahn. "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation" in Proceedings of the National Academy of Sciences of the United States of America (2005) Volume 102, pages 12171-12176. Entrez PubMed 16093313
  4. ^ M. Perez-Moreno, M. A. Davis, E. Wong, H. A. Pasolli, A. B. Reynolds, E. Fuchs. "p120-catenin mediates inflammatory responses in the skin" in Cell (2006) Volume 124, pages 631-644. Entrez PubMed 16469707
v • d • e
Proteins of the cytoskeleton
Microfilaments Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein
Intermediate filaments type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament) - type 5 (Lamin A, B)
Microtubules Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin
Catenins Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin
Nonhuman Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)
Other APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin


 
 

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