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Denham Harman (February 14, 1916 - ), MD, PhD, FACP, FAAA biogerontologist is Professor emeritus at the University of Nebraska Medical Center. Dr. Harman is widely known as the "father of the free radical theory of aging". In 1995 he was nominated for the Nobel Prize in medicine. Gerontology is the study of the elderly, and of the aging process itself. ...
Emeritus (IPA pronunciation: or ) is an adjective that is used in the title of a retired professor, bishop or other professional. ...
The University of Nebraska Medical Center (UNMC) is the a public academic medical center in Omaha, Nebraska. ...
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Free-radical theory. ...
Ageing or aging is the process of getting older. ...
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Background
Denham Harman earned his BS and Ph.D. in 1943 from the College of Chemistry at the University of California, Berkeley and his M.D. from Stanford University, finishing his internship in 1954. The University of California (UC) is a public university system in the state of California. ...
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Immediately after earning his Ph.D., in 1943, Dr. Harman joined the reaction kinetics department of Shell Oil in Emeryville, California. He worked for six years as a Shell research chemist, in part studying free radical reactions in petroleum products. During that period he was granted 35 patents, one for a compound used in plastic strips to catch flies ("Shell No Pest Strip"). In physical chemistry, chemical kinetics or reaction kinetics study reaction rates in a chemical reaction. ...
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Dr. Harman became fascinated with the phenomenon of aging, its cause and possible cure. To assist him in understanding this problem he went to medical school at Stanford University. Harman became chair of cardiovascular research at the University of Nebraska College of Medicine in 1958. Hans Baldung Grien: The Ages And Death, c. ...
A chair or seat is also a seat of office, authority, or dignity, such as the chairperson of a committee, or a professorship at a college or university, or the individual that presides over business proceedings. ...
Dr. Harman has been married to the same woman for most of his life, a journalism student who he met at a fraternity dance while at the University of California. They couple had four children. Dr. Harman maintained a healthy lifestyle throughout his life. He has never smoked and drinks alcohol in moderation. He ran two miles a day until he was 82. He quit because of a back injury, but he continued to take regular walks to help him maintain a weight of 140 pounds on his 5-foot-10 frame. Journalism is a discipline of collecting, analyzing, verifying, and presenting information regarding current events, trends, issues and people. ...
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Development of the Free Radical Theory of Aging In 1954, between his internship and residency in internal medicine, Dr. Harman became a research associated at the Donner Laboratory of Medical Physics at UC Berkeley, where he was able to pursue the puzzle of the cause of aging. After four months of frustration he hit upon the idea of free radicals as cause of the damage to macromolecules known as "aging". Although other scientists were reluctant to accept his theory he was finally able to get it published in what is now a much-cited article in the Journal of Gerontology[1]. A Medical intern, in the context of medical education in the United States, is a historical term for a physician-in-training who has completed medical school, passed step two of the USMLE or COMLEX, and is undergoing his first year of post-graduate training (PGY1). ...
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Internal medicine is concerned with the diagnosis and treatment of internal diseases, that is, those that affect internal organs or the body as a whole. ...
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It has been suggested that this article or section be merged into Ageing. ...
For other uses, see radical. ...
Hans Baldung Grien: The Ages And Death, c. ...
Dr. Harman attempted to detect free radicals in association with the enzyme catalase, but without success. He attempted to do lifespan studies with short-lived strains of mice subject to radiation and given the radiation protection compound 2-MEA (2-mercaptoethylamine), and was able to show a 30% increase in average life expectancy. He was able to show extension of life expectancy with a number of antioxidants. Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ...
Catalase Catalase (human erythrocyte catalase: PDB 1DGF, EC 1. ...
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An antioxidant is a chemical that reduces the rate of particular oxidation reactions in a specific context, where oxidation reactions are chemical reactions that involve the transfer of electrons from a substance to an oxidising agent. ...
In 1961, Dr. Harman published a study showing that the degree of polyunsaturation in fats had a dramatic effect on cancer rates in mice. The most highly polyunsaturated dietary fats were found to be the most carcinogenic. A polyunsaturated organic compound is one in which more than one double bond exists within the representative molecule. ...
When normal cells are damaged beyond repair, they are eliminated by apoptosis. ...
An unsaturated fat is a fat or fatty acid in which there is one or more double bond in the fatty acid chain. ...
In pathology, a carcinogen is any substance or agent that promotes cancer. ...
In 1968 Dr. Harman published a dietary antioxidant study showing that the food preservative BHT fed over a lifetime to mice produced a 45% increase in life span. Dr. Harman became concerned that although many of his studies showed an increase in average lifespan by antioxidants, none showed an increase in maximum lifespan. Flash point 127 °C R/S statement R: 22-36 37 38 S: 26-36 RTECS number GO7875000 Related compounds Related compounds butylated hydroxyanisole Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references BHT is the common...
World map showing Human Life expectancy Life expectancy is the average number of years remaining for a living being (or the average for a class of living beings) of a given age to live. ...
Maximum life span is a measure of the maximum number of years a member of a group has been observed to survive. ...
After years of frustration over his inability to increase maximum lifespan with antioxidant supplements, Dr. Harman came to the conclusion that mitochondria were producing as well as being damaged by free radicals, but that exogenous antioxidants don't enter the mitochondria. And that it is mitochondria that determine lifespan. He published his ideas on what he called the "Mitochondrial Theory of Aging" in the April issue of the Journal of the American Geriatrics Society[2]. In cell biology, a mitochondrion is an organelle found in the cells of most eukaryotes. ...
Exogenous (or exogeneous) (from the Greek words exo and gen, meaning outside and production) refers to an action or object coming from outside a system. ...
Organizational Accomplishments In 1969 Dr. Harman became concerned that few of those involved in gerontology were studying the biological aspects of aging, and fewer still had a serious interest in discovering the cause of aging. In 1970 he became a founder of the American Aging Association (AGE) to create a society of scientists focused on aging research and advocacy of aging research. In 1985 he became a founder of the International Association of Biomedical Gerontology (IABG). Gerontology is the study of the elderly, and of the aging process itself. ...
Biology is the branch of science dealing with the study of life. ...
Hans Baldung Grien: The Ages And Death, c. ...
The American Aging Association (AGE) is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies intended to slow the aging process. ...
See also The American Aging Association (AGE) is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies intended to slow the aging process. ...
The free-radical theory of aging (FRTA) is that organisms age because protein, lipid and nucleic acids (DNA, RNA) accumulate free radical damage with the passage of time. ...
Life extension refers to an increase in maximum or average lifespan, especially in humans, by slowing down or reversing the processes of aging. ...
It has been suggested that this article or section be merged into Ageing. ...
References - ^ Harman, D (1956). "Aging: a theory based on free radical and radiation chemistry". JOURNAL OF GERONTOLOGY 11 (3): 298-300. PMID 13332224.
- ^ Harman, D (1972). "A biologic clock: the mitochondria?". JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 20 (4): 145-147. PMID 5016631.
- Harman D, Harman H (2003). ""I thought, thought, thought for four months in vain and suddenly the idea came"--an interview with Denham and Helen Harman. Interview by K. Kitani and G.O. Ivy". BIOGERONTOLOGY 4 (6): 401-412. PMID 14739712.
External links - About IABG (International Association of Biomedical Gerontology)
- Interview with Denham Harman
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