FACTOID # 130: In Belgium, 55% of government ministers are female. The country’s first female parliamentarian was appointed in 1921.
 
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Encyclopedia > Dermatofibrosarcoma protuberans

Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm of the dermis layer of the skin, and is classified as a sarcoma. In many respects, the disease behaves as a benign tumor, but in 2-5% of cases it can metastasize, so it should be considered to have malignant potential.


Over 95% of DFSP tumors have the chromosomal translocation t(17;22), which results in over-expression of platelet-derived growth factor receptor B (PDGFB).


Treatment is primarily surgical, with chemotherapy and radiation therapy sometimes being used.


There is clinical evidence that imatinib, which inhibits PDGFB, may be effective for tumors positive for the t(17;22) translocation.


  Results from FactBites:
 
Dermatofibrosarcoma Protuberans (DFSP) - Dr Sampurna Roy MD (871 words)
Dermatofibrosarcoma protuberans is a fibrohistiocytic tumour of intermediate malignancy,characterized by a distinctive storiform growth pattern and frequent local recurrences.
Dermatofibrosarcoma protuberans with fibrosarcomatous areas: a clinico-pathologic and immunohistochemic study in four cases.
Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group.
Dermatofibrosarcoma Protuberans (6720 words)
Dermatofibrosarcoma protuberans is genetically characterized by the unbalanced chromosomal t(17;22)(q21;q13), usually in the form of a supernumerary ring chromosome.
Dermatofibrosarcoma protuberans (DFSP) is a dermal and subcutaneous tumor categorized as a tumor of intermediate malignancy, and its progression in some cases to fibrosarcoma is well known.
Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by a distinctive storiform growth pattern and frequent local recurrences.
  More results at FactBites »


 

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