Destination Moon (originally Objectif Lune) is also the title of a comic book in the Tintin series by Hergé; see Destination Moon (Tintin).

Destination Moon is the name of the first postwar-planned American science fiction feature film in the genre of space adventure. It was produced by George Pal in 1950; his technical advisor was Robert Heinlein. It features the notion that US private industry will take it upon itself to fund and produce the first spacecraft to reach the moon, given the Soviet threat at the time, and then the US government will bring itself to buy or lease the machinery. Visionary factory owners are shown trying to raise money amongst themselves to do this. This color film includes an animated segment of Woody Woodpecker illustrating the basics of space flight. Although there were no scenes of the rocket being constructed, a Douglas aircraft plant in Southern California was shown with workers examining a model of the nuclear spacecraft. The only plot element in the picture is that once on the moon, they do not have enough fuel to return, and so must remove a good deal of equipment from the ship. This movie was not the first such to hit the screens, however; Rocketship X-M stole its thunder. The sets and costumes were used in cheap films subsequently, and even appear in the second episode of The Time Tunnel.

"Destination Moon" is the title of a song by Dinah Washington on her Dinah '62 album released by Roulette Records in 1962. "Destination Moon" is also the title of a song by They Might Be Giants from their 1994 album John Henry.