? Image File history File links Dexmedetomidine. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... It has been suggested that this article or section be merged with cell metabolism and carbohydrates. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
Dexmedetomidine is a sedative medication used by intensive care units and anesthesiologists. It is relatively unique in its ability to provide sedation without causing respiratory depression. LIke clonidine, its mechanism of action is agonism of alpha-2 receptors in certain parts of the brain. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ...
Dexmedetomidine is approved for sedation of initially intubated and mechanically ventilated patients in the intensive care setting.
The sedative properties of dexmedetomidine were evaluated by comparing the amount of rescue medication required to achieve a specified level of sedation (using the standardized Ramsay sedation scale).
Dexmedetomidine is supplied in a single 2 mL clear glass vial at a concentration of 100 mcg/mL.
Dexmedetomidine was approved by the Food and Drug Administration at the end of 1999 for use in humans as a short-term medication (<24 hours) for analgesia and sedation in the intensive care unit (ICU).
The average protein binding of dexmedetomidine is 94%, with negligible protein binding displacement by fentanyl, ketorolac, theophylline, digoxin, and lidocaine, all drugs commonly used during anesthesia and in the ICU.
Dexmedetomidine provides better perioperative hemodynamic stability than many agents now in use and may offer protection from ischemia due to the attenuated neuroendocrine response, but the incidence of hypotension and bradycardia requiring intervention during clinical studies was higher in the dexmedetomidine groups than in the placebo groups.
Feeds |
Contact