Diapedesis is the movement of leukocytes across the endothelial lining of blood vessels to interstitial fluid (IF). The process is driven by chemotactic factors. Diapedesis usually happens when an area is injured or damaged and an inflammation response is needed. White Blood Cells is also the name of a White Stripes album. ... The endothelium is the layer of thin, flat cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. ... The arterial system The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Interstitial fluid is one of the two components of extracellular fluid besides plasma. ... Chemotaxis is the phenomenon in which bodily cells, bacteria, and other single-celled or multicellular organisms direct their movements according to certain chemicals in their environment. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ...