LogP is a measure of differential solubility of a compound in two solvents. The log ratio of the concentrations of the solute in the solvent is called LogP or the Partition Coefficient. The most well known of these partition coefficients is the one based on the solvents Octanol and Water. The octanol-water partition coefficient is a measure of the hydrophobicity and hydrophilicity a substance. In the context of drug-like substances, hydrophobicity is related to absorption, bioavailability, hydrophobic drug-receptor interactions, metabolism and toxicity.

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	Soluble - Wikipedia, the free encyclopedia (409 words) The solubility of one substance dissolving in another is determined by the intermolecular forces between the solvent and solute, temperature, the entropy change that accompanies the solvation, the presence and amount of other substances, and sometimes pressure or partial pressure of a solute gas. For inorganic salts, solubility in aqueous solutions is often dependent on a solubility constant. The solubility constant is a special case of an equilibrium constant for the reaction of dissolving the salt in question, with the concentration of undissolved compound not in the expression because it is not in the aqueous phase.
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