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Encyclopedia > Dihydrofolate reductase

  Results from FactBites:
 
Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate ... (5597 words)
Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver.
Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Dihydrofolate reductase - Wikipedia, the free encyclopedia (201 words)
Ribbon diagram of human dihydrofolate reductase in complex with folate (blue).
Dihydrofolate reductase, or DHFR, reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.
A variety of drugs act on dihydrofolate reductase, including the antibiotic trimethoprim, the antimalarial drug pyrimethamine, and the chemotherapeutic agents methotrexate and pemetrexed.
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