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Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate ... (5597 words) |
 | Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver. |
| Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. |
| 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. |
| Dihydrofolate reductase - Wikipedia, the free encyclopedia (201 words) |
| Ribbon diagram of human dihydrofolate reductase in complex with folate (blue). |
| Dihydrofolate reductase, or DHFR, reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. |
| A variety of drugs act on dihydrofolate reductase, including the antibiotic trimethoprim, the antimalarial drug pyrimethamine, and the chemotherapeutic agents methotrexate and pemetrexed. |
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